GCN2 antibody (pThr667) (Biotin)

Catalog No. ABIN684960

The Biotin-conjugated Rabbit Polyclonal anti-GCN2 antibody (ABIN684960) specifically detects GCN2 in WB, ELISA, IHC (p) and IHC (fro). The antibody is reactive with Mouse and Rat samples.

Quick Overview for GCN2 antibody (pThr667) (Biotin) (ABIN684960)

Target: GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCN2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GCN2 Antibody (Biotin)

Binding Specificity: pThr667

Specificity: This phosphorylation site is homologous to Thr666 in Mouse and Thr667 in Rat.

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human GCN2 around the phosphorylation site of Thr667

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GCN2

Target: GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))

Alternative Name: GCN2

Background:

Synonyms: GCN2, PVOD2, Eukaryotic translation initiation factor 2-alpha kinase 4, GCN2-like protein, EIF2AK4, KIAA1338

Background: GCN2 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 to downregulate protein synthesis in response to varied cellular stresses.

Gene ID: 440275

UniProt: Q9P2K8

Pathways: ER-Nucleus Signaling, Hepatitis C