Lamin B Receptor (LBR) antibody

Antigen: Lamin B Receptor (LBR)

Synonyms: PHA, LMN2R, DHCR14B, MGC9041, FLJ43126, dLBR, DmelCG17952, CG17952, Nbp60, ic, AI505894, sb:cb406, zgc:86649, wu:fb75h08, wu:fc47b04, wu:fd36b07, lbr-A, Xp58, p58 gene, LBR, DKFZp469G1019

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN709391

Additional Information

Alternative name: Lamin B Receptor

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Lamin B Receptor

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonym: LMN2R, PHA, DHCR 14B, DHCR14B antibody Integral nuclear envelope inner membrane protein, Lamin-B receptor, LBR, LMN 2R, LMN2R, MGC9041, PHA, PRO0650, DHCR14B, MGC9041.

Molecular Weight: 67-71kDa

Comments:

Lamins are nuclear membrane proteins that serve to maintain specific cellular functions

such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: affinity purified by Protein A

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Restrictions: For Research Use only