Lectin, Galactoside-Binding, Soluble, 3 Binding Protein (LGALS3BP) antibody

Antigen: Lectin, Galactoside-Binding, Soluble, 3 Binding Protein (LGALS3BP)

Synonyms: 90K, BTBD17B, MAC-2-BP, Ppicap, MGC93166

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine)

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN713876

Additional Information

Alternative name: LGALS3BP

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human LGALS3BP

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonym: Mac 2 binding protein, MAC2BP, Tumor associated antigen 90K, 90K, 90K MAC 2 BP, Basement membrane autoantigen p105, Galectin 3 binding protein, L3 antigen, Lectin galactoside binding soluble 3 binding protein, M2BP, Mac 2 BP, Serum protein 90K.

Molecular Weight: 65kDa

Comments:

LGALS3BP is a ligand of galectin 3

and has been suggested to influence tumor proliferation and metastasis formation. Galectins and their ligands have been implicated in cell transformation and cancer metastasis

and found to have prognostic value. LGALS3BP also known as Mac 2 BP

and as 90K

is a highly glycosylated

secreted protein extensively studied in human cancer

which binds galectin 1

galectin 3 and galectin 7. High expression levels of this molecule are associated with a shorter survival

the occurrence of metastasis or a reduced response to chemotherapy in patients with different types of malignancy. The mechanisms underlying the prognostic significance of 90K and galectins in cancer are far from being understood

although they may be related to the ability of these proteins to interact and

to some extent

modulate cell cell and cell matrix adhesion and apoptosis.

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: affinity purified by Protein A

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Research Area: Cancer, Cell Cycle

Restrictions: For Research Use only