ZC3H12A antibody (AA 201-300) (Biotin)

Catalog No. ABIN714823

This Rabbit Polyclonal antibody specifically detects ZC3H12A in WB, ELISA and IHC (fro). It exhibits reactivity toward Human and Mouse.

Quick Overview for ZC3H12A antibody (AA 201-300) (Biotin) (ABIN714823)

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZC3H12A antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ZC3H12A Antibody (Biotin)

Binding Specificity: AA 201-300

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MCPIP1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ZC3H12A

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Alternative Name: MCPIP1

Background:

Synonyms: dJ423B22.1, MCP 1 treatment-induced protein, MCP-induced protein 1, MCPIP 1, MCPIP, Ribonuclease ZC3H12A, RP3-423B22.1, ZC12A_HUMAN, ZC3H 12A, ZC3H12 A, Zc3h12a, Zinc finger CCCH domain-containing protein 12A, Zinc finger CCCH type containing 12A.

Background: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.

Gene ID: 80149

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation