ADAMTS10 antibody (AA 851-950) (HRP)

Catalog No. ABIN718505

The Rabbit Polyclonal anti-ADAMTS10 antibody is suitable to detect ADAMTS10 in samples from Human. It has been validated for ELISA, IHC (fro) and IHC (p).

Quick Overview for ADAMTS10 antibody (AA 851-950) (HRP) (ABIN718505)

Target: ADAMTS10 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 10 (ADAMTS10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS10 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ADAMTS10 Antibody (HRP)

Binding Specificity: AA 851-950

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADAMTS10

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ADAMTS10

Target: ADAMTS10 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 10 (ADAMTS10))

Alternative Name: ADAMTS10

Background:

Synonyms: A disintegrin and metalloproteinase with thrombospondin mots 10, A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 mot, 10, ADAM metallopeptidase with thrombospondin type 1 mot 10, ADAM TS10, EC 3.4.24, WMS, ATS10_HUMAN.

Background: ADAMTS10 is a member of the ADAMs family of proteinases with Thrombospondin motifs. The catalytic site of ADAMTS10 is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence, perhaps giving these enzymes some shared specificity. ADAMTS10 is closest in homology to ADAMTS6, sharing 53 % overall identity. Functional mutations in ADAMTS10 have been linked to Weill Marchesani syndrome, a connective tissue disorder marked by fibrillin 1 misprocessing. ADAMTS10 has also been reported to be over expressed in breast cancer tissues and cell lines.

Gene ID: 81794