BMPR1B antibody (AA 61-160)

Catalog No. ABIN719246

The Rabbit Polyclonal anti-BMPR1B antibody is suitable to detect BMPR1B in samples from Human. It has been validated for WB and ELISA.

Quick Overview for BMPR1B antibody (AA 61-160) (ABIN719246)

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BMPR1B Antibody

Binding Specificity: AA 61-160

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BMPR1B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BMPR1B

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Alternative Name: BMPR1B

Background:

Synonyms: BMPR-IB, Activin receptor like kinase 6, Acvrlk6, ALK 6, ALK6, alk6tr, BMP type-1B receptor, BMPR IB, BMPR-1B, Bmpr1b, BMPRIB, BMR1B_HUMAN, Bone morphogenetic protein receptor type 1B, Bone morphogenetic protein receptor type IB, Bone morphogenetic protein receptor type-1B, BR 1b, BR1b, CDw 293, CDw293, CDw293 antigen, CFK 43a, CFK43a, Serine/threonine receptor kinase, zALK 6, zALK6.

Background: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.Involvement in disease, Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA). Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers).Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo.

Gene ID: 658