Ldha/Ldh antibody

Catalog No. ABIN734768

The Rabbit Polyclonal anti-Ldha/Ldh antibody is suitable to detect Ldha/Ldh in samples from Human, Mouse and Rat. It has been validated for WB, IF (p) and IHC (p).

Quick Overview for Ldha/Ldh antibody (ABIN734768)

Target: Ldha/Ldh

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LDH

Isotype: IgG

Application Details

Application Notes: WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details

Target: Ldha/Ldh

Background:

Synonyms: Lactate Dehydrogenase, Lactate Dehydrogenase Isoenzyme V, Lactate Dehydrogenase isozyme H4, L lactate dehydrogenase A chain, Lactate dehydrogenase A, Lactate dehydrogenase A chain, LDH A, LDH heart subunit, LDH M, LDHM, LDH muscle subunit, LDH1, LDHA, PIG 19, PIG19, Proliferation inducing gene 19 protein, TRG 5, TRG5, LDHA_HUMAN.

Background: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.Lactate dehydrogenase is an enzyme present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. Isoforms of the enzyme include LDH 1 (4H) in the heart, LDH 2 (3H1M) in the reticuloendothelial system, LDH 3 (2H2M) in the lungs, LDH 4 (1H3M) in the kidneys and LDH 5 (4M) in the liver and striated muscle. The M and H subunits are encoded by two different genes.

Gene ID: 3939