CACNA1A antibody (AA 1401-1500) (Biotin)

Catalog No. ABIN751305

The Biotin-conjugated Rabbit Polyclonal anti-CACNA1A antibody (ABIN751305) specifically detects CACNA1A in ELISA, IHC (fro) and IHC (p). The antibody is reactive with Rat samples.

Quick Overview for CACNA1A antibody (AA 1401-1500) (Biotin) (ABIN751305)

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1A antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CACNA1A Antibody (Biotin)

Binding Specificity: AA 1401-1500

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CACNA1A

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CACNA1A

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Alternative Name: CACNA1A/Cav2.1

Background:

Synonyms: APCA, BI, Brain calcium channel 1, Brain calcium channel I, Cach4, Cacn3, Cacna1a, Cacnl1a4, Calcium channel alpha 1A subunit, Calcium channel L type alpha 1 polypeptide, Calcium channel L type alpha-1 polypeptide isoform 4, Calcium channel voltage dependent, P/Q type alpha 1A subunit, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, RAT brain class A, RBA-I, SCA6, Voltage-dependent P/Q-type calcium channel alpha-1A subunit, Voltage-gated calcium channel alpha subunit Cav2.1, CAC1A_HUMAN.

Background: Cav2.1 is a voltage-sensitive calcium channels (VSCC) which belongs to the calcium channel alpha-1 subunit family. Cav2.1 mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Cav2.1 (isoform alpha-1A) gives rise to P and/or Q-type calcium currents. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Gene ID: 773

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process