ZMYM2 antibody (N-Term)

Catalog No. ABIN783367

This Rabbit Polyclonal antibody specifically detects ZMYM2 in WB and EIA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for ZMYM2 antibody (N-Term) (ABIN783367)

Target: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZMYM2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ZMYM2 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects ZMYM2 at N-term. At least two isoforms of ZMYM1 are known to exist, this antibody will detect only the shorter isoform. ZMYM1 antibody is predicted to not cross-react with other ZMYM protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the amino terminus of human ZMYM1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for ZMYM2

Target: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Alternative Name: ZMYM2

Background: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM1 is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing. While its function remains unknown, the related protein ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes, suggesting that ZMYM1 may play a similar role.Synonyms: FIM, Fused in myeloproliferative disorders protein, RAMP, Rearranged in atypical myeloproliferative disorder protein, ZNF198, Zinc finger MYM-type protein 2, Zinc finger protein 198

Gene ID: 7750

NCBI Accession: NP_001177893

UniProt: Q9UBW7