RABGEF1 antibody (Center)

Catalog No. ABIN783421

This Rabbit Polyclonal antibody specifically detects RABGEF1 in WB and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RABGEF1 antibody (Center) (ABIN783421)

Target: RABGEF1 (RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RABGEF1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-RABGEF1 Antibody

Binding Specificity: Center

Specificity: This antibody detects RABGEF1 at Center. At least four isoforms of RABEX5 are known to exist, this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the center terminus of human RABEX5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for RABGEF1

Target: RABGEF1 (RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1))

Alternative Name: RABGEF1

Background: RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.Synonyms: RABEX5, RAP1, Rab5 GDP/GTP exchange factor, Rabaptin-5-associated exchange factor for Rab5, Rabex-5

Gene ID: 27342

NCBI Accession: NP_055319

UniProt: Q9UJ41

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process