KAL1 antibody (Center)

Catalog No. ABIN783480

Product Details anti-KAL1 Antibody

Target: KAL1 (Kallmann Syndrome 1 Sequence (KAL1))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KAL1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Anosmin (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography

Immunogen: Raised against an 18 amino acid peptide near the center of human Anosmin

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for KAL1

Target: KAL1 (Kallmann Syndrome 1 Sequence (KAL1))

Alternative Name: Anosmin-1 (KAL1 Products)

Synonyms: ADMLX antibody, HH1 antibody, HHA antibody, KAL antibody, KALIG-1 antibody, KMS antibody, WFDC19 antibody, KAL1 antibody, hha antibody, kal antibody, kms antibody, admlx antibody, kalig-1 antibody, anosmin-1a antibody, kal1.1 antibody, kal1a antibody, wu:fl91z45 antibody, anosmin 1 antibody, anosmin 1a antibody, ANOS1 antibody, anos1 antibody, anos1a antibody

Background: Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.Synonyms: ADMLX, Adhesion molecule-like X-linked, KAL, KAL1, KALIG1, Kallmann syndrome protein

Gene ID: 3730

NCBI Accession: NP_000207

UniProt: P23352