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NLR Family, Pyrin Domain Containing 5 (NLRP5) (C-Term) antibody

Details for Product No. ABIN783707, Supplier: Login to see
Antigen
  • CLR19.8
  • MATER
  • NALP5
  • PAN11
  • PYPAF8
  • Mater
  • Nalp5
  • Op1
Epitope
C-Term
6
3
Reactivity
Human, Mouse (Murine), Rat (Rattus)
12
7
7
Host
Rabbit
13
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
12
8
5
3
1
1
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Immunogen 14 amino acid peptide near the carboxy terminus of human NALP5
Specificity This antibody detects NLRP5 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography purified via peptide column
Alternative Name NLRP5 (NLRP5 Antibody Abstract)
Background NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.Synonyms: LRR and PYD domains-containing protein 5, MATER, NALP5
Gene ID 126206
NCBI Accession NP_703148
UniProt P59047
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, Pyrin Domain Containing 5 (NLRP5) (C-Term) antibody (ABIN783707) Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 ...
Background publications Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).