NLR Family, Pyrin Domain Containing 5 (NLRP5) (C-Term) antibody

Details for Product No. ABIN783707
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Synonyms Nalp5, Op1, Mater, PAN11, CLR19.8, MATER, NALP5, PYPAF8
(7), (2), (1)
Human, Mouse (Murine), Rat (Rattus)
(13), (6), (6)
(12), (1)
ELISA, Western Blotting (WB)
(12), (9), (5), (1)
Pubmed 2 references available
Catalog no. ABIN783707
Quantity 0.1 mg
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Immunogen 14 amino acid peptide near the carboxy terminus of human NALP5
Specificity This antibody detects NLRP5 at C-term. Species Reactivity: Tested: Human, mouse, rat
Purification Affinity chromatography purified via peptide column
Alternative Name NLRP5
Background NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Alternate names: LRR and PYD domains-containing protein 5, MATER, NALP5
Gene ID 126206
NCBI Accession NP_703148
UniProt P59047
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

Hosts (12), (1)
Reactivities (13), (6), (6)
Applications (12), (9), (5), (1)
Epitopes (7), (2), (1)
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