NLRP5 antibody (C-Term)

Catalog No. ABIN6991402

Product Details anti-NLRP5 Antibody

Target: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: NALP5 Antibody is affinity chromatography purified via peptide column.

Immunogen: NALP5 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5. The immunogen is located within the last 50 amino acids of NALP5.

Isotype: IgG

Application Details

Application Notes: NALP5 antibody can be used for detection of NALP5 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NALP5 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NALP5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NLRP5

Target: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Alternative Name: NALP5 (NLRP5 Products)

Synonyms: CLR19.8 antibody, MATER antibody, NALP5 antibody, PAN11 antibody, PYPAF8 antibody, Mater antibody, Nalp5 antibody, Op1 antibody, NLR family pyrin domain containing 5 antibody, NLR family, pyrin domain containing 5 antibody, NLRP5 antibody, Nlrp5 antibody

Background: NALP5 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.

Gene ID: 126206

NCBI Accession: NP_703148

UniProt: P59047

Pathways: Inflammasome