SAMHD1 antibody

Catalog No. ABIN2731372

There are 4+ publications for this product available. The Mouse Monoclonal anti-SAMHD1 antibody is suitable to detect SAMHD1 in samples from Human, Mouse, Rat, Monkey and Dog. It has been validated for WB, IHC, IF and FACS.

Quick Overview for SAMHD1 antibody (ABIN2731372)

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Reactivity: Human, Mouse, Rat, Monkey, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This SAMHD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 3F5

Product Details anti-SAMHD1 Antibody

Characteristics: Homo sapiens SAM domain and HD domain 1 (SAMHD1)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human SAMHD1(NP_056289) produced in HEK293T cell.

Isotype: IgG2b

Application Details

Application Notes: WB 1:200~500, IHC 1:150, IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-SAMHD1 antibody (ABIN2731372)

Daddacha, Koyen, Bastien, Head, Dhere, Nabeta, Connolly, Werner, Madden, Daly, Minten, Whelan, Schlafstein, Zhang, Anand, Doronio, Withers, Shepard, Sundaram, Deng, Dynan, Wang, Bindra, Cejka et al.: "SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. ..." in: Cell reports, Vol. 20, Issue 8, pp. 1921-1935, (2018) (PubMed).

Oh, Ryoo, Park, Kim, Daly, Cho, Ahn: "A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature." in: Scientific reports, Vol. 8, Issue 1, pp. 84, (2018) (PubMed).

Jáuregui, Landau: "DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1." in: Scientific reports, Vol. 8, Issue 1, pp. 4153, (2018) (PubMed).

Wittmann, Behrendt, Eissmann, Volkmann, Thomas, Ebert, Cribier, Benkirane, Hornung, Bouzas, Gramberg: "Phosphorylation of murine SAMHD1 regulates its antiretroviral activity." in: Retrovirology, Vol. 12, pp. 103, (2015) (PubMed).

Target Details for SAMHD1

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Alternative Name: SAMHD1

Molecular Weight: 72 kDa

Gene ID: 25939

NCBI Accession: NM_015474

HGNC: 25939