Glucagon antibody

Catalog No. ABIN865480

This Mouse Monoclonal antibody specifically detects Glucagon in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for Glucagon antibody (ABIN865480)

Target: Glucagon (GCG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Glucagon antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2F9

Product Details anti-Glucagon Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human GCG expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Glucagon

Target: Glucagon (GCG)

Alternative Name: GCG

Background: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Synonyms: GLP1, GLP2, GRPP, GCG

Molecular Weight: 21kDa

Gene ID: 2641

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling