Factor VIII antibody (C-Term)

Catalog No. ABIN929428

This Rabbit Polyclonal antibody specifically detects Factor VIII in WB. It exhibits reactivity toward Human.

Quick Overview for Factor VIII antibody (C-Term) (ABIN929428)

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor VIII antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Factor VIII Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: F8 antibody was raised in rabbit using the C terminal of F8 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

F8 Blocking Peptide, (ABIN938955), is also available for use as a blocking control in assays to test for specificity of this F8 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Alternative Name: F8

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. Synonyms: Polyclonal F8 antibody, Anti-F8 antibody, coagulation factor VIII, procoagulant component antibody, AHF antibody, DXS1253E antibody, F8B antibody, F8C antibody, FVIII antibody, HEMA antibody.