Selectin L (SELL) antibody

Antigen: Selectin L (SELL)

Synonyms: TQ1, LAM1, LNHR, LSEL, CD62L, LAM-1, LYAM1, Leu-8, PLNHR, hLHRc, LECAM1, Lyam-1, Lnhr, Ly-22, Lyam1, Ly-m22, LECAM-1, AI528707, L-selectin

Clonality: Monoclonal (LT-TD180)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS)

Catalog no.: ABIN94210

Additional Information

Alternative name: CD62L

Immunogen: Peripheral blood leukocytes

Format: Purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: LT-TD180

Description: CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cellsurface of leukocytes and mediates their homing to inflammatory sites and peripheral lymphnodes by enabling rolling along the venular wall. CD62L is also involved inactivation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however,counteracts neutrophil rolling. CD62L has also signaling roles including enhance ofchemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1(P-selectin glycoprotein ligand-1).

Specificity: The antibody LT-TD180 reacts with CD62L (L-selectin), a 74-95 kDa single chain type Iglycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytesand granulocytes, it is also present on a subset of NK cells and certain hematopoieticmalignant cells.

Application Details

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE)

Purification: Purified from ascites by precipitation methods and ion exchange chromatography.

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only

Images

Surface staining of human peripheral blood cells with anti-CD62L (LT-TD180) Pacific Blue (lymphocyte gate).