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TEK Tyrosine Kinase, Endothelial (TEK) (AA 19-745) antibody

Details for Product No. ABIN951221
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Antigen
Synonyms TEK, DKFZp469E064, AA517024, Cd202b, Hyk, Tie2, tie-2, CD202B, TIE-2, TIE2, VMCM, VMCM1, Tie-2, tie2
Epitope
AA 19-745
(18), (17), (17), (16), (12), (11), (9), (6), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(184), (121), (71), (66), (65), (48), (48), (1), (1)
Host
Rabbit
(133), (51), (24), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(19), (10), (8), (7), (5), (5), (5), (5), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1)
Application
Western Blotting (WB)
(112), (92), (59), (54), (26), (24), (12), (8), (7), (5), (4), (4), (1), (1)
Pubmed 3 references available
Quantity 0.2 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN951221
500.50 $
Plus shipping costs $45.00

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Immunogen Highly pure (>95%) recombinant Human soluble TIE-2 (Thr19-Lys745) derived from Insect cells.
Isotype IgG
Specificity Recognizes TIE-2 (CD202b/TEK)
Purification Protein A Chromatography
Alternative Name CD202b / TEK
Background TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/TEK comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2), which bind TIE-2 with high affinity have been identified. Ang2 has been reported to act as an antagonist for Ang1. Mice engineered to overexpress Ang2 or to lack Ang1 or TIE-2 display similar angiogenic defects.
Alternate names: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK
Gene ID 7010
NCBI Accession NP_000450
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Reconstitution Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
Buffer PBS, pH 7.2
Storage 4 °C/-20 °C
Storage Comment The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. Avoid repeated freeze-thaw cycles!
Expiry Date 1 month
Background publications Takakura, Huang, Naruse et al.: "Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis." in: Immunity, Vol. 9, Issue 5, pp. 677-86, 1998 (PubMed).

Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999 (PubMed).

Procopio, Pelavin, Lee et al.: "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30196-201, 1999 (PubMed).

Validation Images
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