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C-Fos antibody

Antigen

C-Fos
Clonality Polyclonal
Host
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN965712
Quantity 100myg
Price 316.25 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide corresponding to a sequence at the middle region of human C-FOS, identical to the related rat and mouse sequence.
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Description The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome.1 c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation.2 Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease. 3

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Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative 0.05mg Thiomersal, 0.05mg NaN3.
Storage At -20°C for one year. After reconstitution, at 4°C for one month.
Restrictions For Research Use only

Publications
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Product Barker, Rabin, Watson et al.: "Human c-fos oncogene mapped within chromosomal region 14q21----q31." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 18, pp. 5826-30, 1984 (PubMed).

Saez, Rutberg, Mueller et al.: "c-fos is required for malignant progression of skin tumors." in: Cell, Vol. 82, Issue 5, pp. 721-32, 1995 (PubMed).

Grigoriadis, Wang, Wagner: "Fos and bone cell development: lessons from a nuclear oncogene." in: Trends in genetics : TIG, Vol. 11, Issue 11, pp. 436-41, 1996 (PubMed).

Alternatives
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Alternatives for antigen "C-Fos", type "Antibodies"
Hosts Rabbit (90), Mouse (20), Sheep (11), Goat (2), Chicken (1)
Reactivities Human (102), Mouse (Murine) (51), Rat (Rattus) (48), Pig (Porcine) (27), Dog (Canine) (11), Chicken (6), Cow (Bovine) (5), Sheep (Ovine) (5)
Applications Western Blotting (WB) (81), ELISA (45), Immunofluorescence (IF) (32), Immunohistochemistry (IHC) (27), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (22), Immunocytochemistry (ICC) (5), Immunoprecipitation (IP) (5), Flow Cytometry (FACS) (3), Immunohistochemistry (Fixed) (IHC (fx)) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Dot Blot (Dot) (2), Electrophoretic Mobility-Shift Assay (EMSA) (1), Gel Shift (GS) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (4), Alexa Fluor 488 (4), Alexa Fluor 555 (4), Alexa Fluor 647 (4), PE,Cy5.5 (4), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pThr232 (11), C-Term (7), N-Term (7), Internal Region (6), pSer32 (6), pThr325 (5), AA 4-17 (3), pSer374 (2), AA 168-380 (1), AA 2-17 (1), AA 75-155 (1), pSer362 (1), pTyr969 (1)