DCK antibody (N-Term)

Catalog No. ABIN965975

The Rabbit Polyclonal anti-DCK antibody has been validated for IHC. It is suitable to detect DCK in samples from Human. There is 1 publication available.

Quick Overview for DCK antibody (N-Term) (ABIN965975)

Target: DCK (Deoxycytidine Kinase (DCK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCK antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DCK Antibody

Binding Specificity: N-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DCK (deoxycytidine kinase)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-DCK antibody (ABIN965975)

Innoceta, Galluzzi, Ruzzo, Andreoni, Chiarantini, Magnani: "Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells." in: Molecular and cellular biochemistry, Vol. 231, Issue 1-2, pp. 173-7, (2002) (PubMed).

Target Details for DCK

Target: DCK (Deoxycytidine Kinase (DCK))

Alternative Name: DCK

Background: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.