DISC1 antibody (C-Term)

Catalog No. ABIN965998

This Rabbit Polyclonal antibody specifically detects DISC1 in IHC. It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for DISC1 antibody (C-Term) (ABIN965998)

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISC1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DISC1 Antibody

Binding Specificity: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DISC1(Disrupted in schizophrenia 1 protein)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-DISC1 antibody (ABIN965998)

Taylor, Devon, Millar, Porteous: "Evolutionary constraints on the Disrupted in Schizophrenia locus." in: Genomics, Vol. 81, Issue 1, pp. 67-77, (2003) (PubMed).

Morris, Kandpal, Ma, Austin: "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation." in: Human molecular genetics, Vol. 12, Issue 13, pp. 1591-608, (2003) (PubMed).

Ozeki, Tomoda, Kleiderlein, Kamiya, Bord, Fujii, Okawa, Yamada, Hatten, Snyder, Ross, Sawa: "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 1, pp. 289-94, (2003) (PubMed).

Millar, Wilson-Annan, Anderson, Christie, Taylor, Semple, Devon, St Clair, Muir, Blackwood, Porteous: "Disruption of two novel genes by a translocation co-segregating with schizophrenia." in: Human molecular genetics, Vol. 9, Issue 9, pp. 1415-23, (2000) (PubMed).

Seki, Ohira, Nagase, Ishikawa, Miyajima, Nakajima, Nomura, Ohara: "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 4, Issue 5, pp. 345-9, (1998) (PubMed).

Target Details for DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Alternative Name: DISC1 (Disrupted in schizophrenia 1 protein)

Background: DISC1 (Disrupted in schizophrenia 1 protein) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is involved in neurite outgrowth and cortical development through its interaction with other proteins. DISC1 interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. The interaction with microtubules may be mediated in part by TRAF3IP1. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1,11)(q42.1,q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.

Pathways: Regulation of Cell Size