DTNBP1 antibody (N-Term)

Catalog No. ABIN966013

This Rabbit Polyclonal antibody specifically detects DTNBP1 in IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for DTNBP1 antibody (N-Term) (ABIN966013)

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DTNBP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DTNBP1 Antibody

Binding Specificity: N-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DTNBP1(Dystrobrevin binding protein 1)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for DTNBP1

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Alternative Name: DTNBP1(Dystrobrevin binding protein 1)

Background: DTNBP1(Dystrobrevin binding protein 1)plays a role in the biogenesis of lysosome-related organelles such as platelet dense granule and melanosomes. Dystrobrevin binding protein 1 binds to alpha and beta dystrobrevins that are components of the dystrophin-associated protein complex (DPC). It interacts with pallidin and MUTED. Dystrobrevin binding protein 1 is a part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Defects in DTNBP1 are the cause of Hermansky-Pudlak syndrome 7 (HPS7). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. Dystrobrevin binding protein 1 belongs to the dysbindin family.

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling