ELP3 (C-Term) antibody

Antigen: ELP3

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine)

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966066

Additional Information

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ELP3(elongation protein 3 homolog)

Description: Elongator is a component of early elongation complexes formed in cell nuclear extracts and can interact directly with RNA polymerase II. ELP contains four isoforms: ELP1, ELP2, ELP3, and Ad4BP/SF1. ELP1 functioned as a repressor. The ELP2, ELP3, and Ad4BP/SF1 functioned as transactivators. Complex patterns of expression of these isoforms were observed in various tissues. All four ELP isoforms were expressed only in EC cells.

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Purification: Purified by antigen-specific affinity chromatography.

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: 0.01% Sodium Azide

Storage: Store at -20°C.

Restrictions: For Research Use only

Publications

Product: Ninomiya, Okada, Kotomura et al.: "Genomic organization and isoforms of the mouse ELP gene." in: Journal of biochemistry, Vol. 118, Issue 2, pp. 380-9, 1996 (PubMed).

Hawkes, Otero, Winkler et al.: "Purification and characterization of the human elongator complex." in: The Journal of biological chemistry, Vol. 277, Issue 4, pp. 3047-52, 2002 (PubMed).