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FES antibody (Feline Sarcoma Oncogene)

Details for Product anti-FES Antibody No. ABIN966135, Supplier: Log in to see
Antigen
  • FES
  • c-fps
  • FPS
  • AI586313
  • BB137047
  • c-fes
  • RGD1564385
Reactivity
Human
74
23
15
1
1
1
Host
Mouse
45
28
2
Clonality (Clone)
Monoclonal ()
Conjugate
This FES antibody is un-conjugated
1
Application
ELISA, Western Blotting (WB)
64
37
24
5
3
2
2
2
1
Supplier
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Immunogen Purified recombinant fragment of FES expressed in E. Coli.
Clone 5A11G5
Isotype IgG1
Purification Ascitic fluid
Alternative Name FES (FES Antibody Abstract)
Background FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosinespecific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
Synonyms: FPS
Gene ID 2242
Research Area Cancer, Tyrosine Kinases
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Vitenzon, Mironov, Petrushanskaya: "Functional electrostimulation of muscles as a method for restoring motor functions." in: Neuroscience and behavioral physiology, Vol. 35, Issue 7, pp. 709-14, 2006 (PubMed).

Background publications Delfino, Stevenson, Smithgall: "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer." in: The Journal of biological chemistry, Vol. 281, Issue 13, pp. 8829-35, 2006 (PubMed).

Durfee, Rivard: "Design and simulation of a pneumatic, stored-energy, hybrid orthosis for gait restoration." in: Journal of biomechanical engineering, Vol. 127, Issue 6, pp. 1014-9, 2006 (PubMed).