MEF2 (C-Term) antibody

Antigen: MEF2

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966551

Additional Information

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human MEF2 (myocyte enhancer factor 2)

Description: The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. A family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many muscle-specific genes. The MEF2 genes are members of the MADS gene family, a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNAbinding domain.

Application Details

Restrictions: For Research Use only

Publications

Product: McDermott, Cardoso, Yu et al.: "hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors." in: Molecular and cellular biology, Vol. 13, Issue 4, pp. 2564-77, 1993 (PubMed).

Hobson, Krahe, Garcia et al.: "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23." in: Genomics, Vol. 29, Issue 3, pp. 704-11, 1996 (PubMed).

Krainc, Haas, Ward et al.: "Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved." in: Genomics, Vol. 29, Issue 3, pp. 809-11, 1996 (PubMed).

Molkentin, Li, Olson: "Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity." in: The Journal of biological chemistry, Vol. 271, Issue 29, pp. 17199-204, 1996 (PubMed).

Vega, Salas, Milne et al.: "Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study." in: Gynecologic oncology, Vol. 112, Issue 1, pp. 210-4, 2008 (PubMed).

Zhao, Geng, Ge et al.: "Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells." in: Molecular and cellular biochemistry, Vol. 322, Issue 1-2, pp. 171-8, 2009 (PubMed).