Matrix Metallopeptidase 10 (Stromelysin 2) (MMP10) (C-Term,AA 410-422) antibody

Antigen: Matrix Metallopeptidase 10 (Stromelysin 2) (MMP10)

Binding Site: C-Term,AA 410-422

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN966586

Additional Information

Alternative name: MMP-10

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human MMP-10 (410-422 aa), identical to the related mouse and rat sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Application Details

Application Notes: WB: The detection limit for MMP-10 is approximately 2.5ng/lane under non-reducing and reducing conditions.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Research Area: Extracellular Matrix

Restrictions: For Research Use only

Publications

Product: Jung, Warter, Rumpler: "Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization." in: Annales de génétique, Vol. 33, Issue 1, pp. 21-3, 1990 (PubMed).

Muller, Quantin, Gesnel et al.: "The collagenase gene family in humans consists of at least four members." in: The Biochemical journal, Vol. 253, Issue 1, pp. 187-92, 1988 (PubMed).