SETDB1 antibody

Catalog No. ABIN967016

Product Details anti-SETDB1 Antibody

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Reactivity: Human, Mouse, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This SETDB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human SETDB1 expressed in E. Coli.

Clone: 5H6D4

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-SETDB1 antibody (ABIN967016)

Gao, Yu, Bi, Jiang, Cui, Sun, Ma: "Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression." in: Molecular and cellular biochemistry, Vol. 305, Issue 1-2, pp. 35-44, (2007) (PubMed).

Target Details for SETDB1

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Alternative Name: SETDB1 (SETDB1 Products)

Background: This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-Lmethionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression.
Tissue specificity: Widely expressed. High expression in testis.
Synonyms: ESET, KG1T, KMT1E, KIAA0067, H3-K9-HMTase4, SETDB1

Molecular Weight: 180kDa

Gene ID: 9869