CD47 (CD47) antibody

Details for Product No. ABIN967480
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Antigen
Synonyms 9130415E20Rik, AA407862, AI848868, AW108519, B430305P08Rik, IAP, Itgp, MER6, OA3, CD47/IAP
Reactivity
Mouse (Murine)
(101), (38), (22), (5), (3), (2), (2), (2), (2), (1), (1)
Host
Rat
(89), (38), (5), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(21), (10), (6), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
(104), (58), (41), (20), (16), (10), (9), (8), (7), (7), (6), (5), (5), (2), (2)
Pubmed 7 references available
Quantity 0.5 mg
Options
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Catalog No. ABIN967480
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Clone Miap301
Isotype IgG2a, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD47 (IAP)
Background The miap301 antibody reacts with the extracellular domain of CD47, also known as Integrin-Associated Protein (IAP).1 CD47 is a 50-kDa plasma membrane protein with an extracellular immunoglobulin variable region-like domain, a multiple membrane-spanning segment, and a short C-terminal cytoplasmic tail. IAP is often physically associated with beta3 integrins, and it may act as a transducer element in activation mediated by these integrins.CD47 is expressed by a wide variety of cell types, including some cells lacking integrins, such as erythrocytes. The cytoplasmic tail region is expressed as alternatively spliced forms, which are differentially expressed in diverse tissues, suggesting that IAP may have distinct functions in various tissues. CD47 and its ligand, CD172a, are proposed to mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages.
Synonyms: IAP
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Lindberg, Gresham, Schwarz et al.: "Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding." in: The Journal of cell biology, Vol. 123, Issue 2, pp. 485-96, 1993 (PubMed).

Reinhold, Lindberg, Plas et al.: "In vivo expression of alternatively spliced forms of integrin-associated protein (CD47)." in: Journal of cell science, Vol. 108 ( Pt 11), pp. 3419-25, 1996 (PubMed).

Lindberg, Bullard, Caver et al.: "Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice." in: Science (New York, N.Y.), Vol. 274, Issue 5288, pp. 795-8, 1996 (PubMed).

Jiang, Lagenaur, Narayanan: "Integrin-associated protein is a ligand for the P84 neural adhesion molecule." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 559-62, 1999 (PubMed).

Mi, Jiang, Weng et al.: "Expression of a synapse-associated membrane protein, P84/SHPS-1, and its ligand, IAP/CD47, in mouse retina." in: The Journal of comparative neurology, Vol. 416, Issue 3, pp. 335-44, 2000 (PubMed).

Gresham, Dale, Potter et al.: "Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr." in: The Journal of experimental medicine, Vol. 191, Issue 3, pp. 515-28, 2000 (PubMed).

Oldenborg, Zheleznyak, Fang et al.: "Role of CD47 as a marker of self on red blood cells." in: Science (New York, N.Y.), Vol. 288, Issue 5473, pp. 2051-4, 2000 (PubMed).

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