anti-Caspase 4 antibody (Caspase 4, Apoptosis-Related Cysteine Peptidase)

Details for Product anti-CASP4 Antibody No. ABIN967534
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Synonyms CASP4, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX, Casp11, Caspl, ich-3, CASP1, CASP13
(167), (77), (30), (20), (3), (1), (1)
(179), (23), (17), (16), (7)
Clonality (Clone)
Monoclonal ()
This Caspase 4 antibody is un-conjugated
(14), (11), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(211), (102), (56), (49), (19), (18), (10), (10), (7), (6), (3), (3), (2)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States ( )
Brand BD Pharmingen™
Immunogen Recombinant Human Caspase-4
Clone B25-1
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Caspase-4 (CASP4 Antibody Abstract)
Background Caspase-4 (ICErelII, TX, ICH-2) is a 43 kDa cytosolic protein with homology to the ICE/Ced-3 family of cysteine proteases. Functional similarity with ICE proteases include the ability of Caspase-4 to induce apoptosis when overexpressed. Caspase-4 exhibits protease activity, cleaving both itself and the p30 ICE/caspase-1 proenzyme. However, unlike ICE/caspase-1, caspase-4 displays no IL-1beta processing activity. Caspase-4 mRNA is expressed in most adult human tissues, suggesting a broad tissue distribution. The B25-1 antibody recognizes an ~43 kDa band corresponding to human Caspase-4 (TX). A recombinant human Caspase-4 protein fragment corresponding to amino acids 334-377 was used as immunogen.
Synonyms: TX, Ich-2
Molecular Weight 43 kDa
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Applications include western blot analysis (1-2 µg/ml). Jurkat T cells (ATCC TIB- 152) and 293 adenovirus-transformed human kidney cells (ATCC CRL-1573) are suggested as positive controls.

Related Products: ABIN967389, ABIN968537

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-Caspase 4 antibody (Caspase 4, Apoptosis-Related Cysteine Peptidase) (ABIN967534) Western blot analysis of Caspase-4 (TX). Lysates from 293 adenovirus-transformed huma...
Image no. 2 for anti-Caspase 4 antibody (Caspase 4, Apoptosis-Related Cysteine Peptidase) (ABIN967534) anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (Image 2)
Background publications Munday, Vaillancourt, Ali et al.: "Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases." in: The Journal of biological chemistry, Vol. 270, Issue 26, pp. 15870-6, 1995 (PubMed).

Faucheu, Diu, Chan et al.: "A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells." in: The EMBO journal, Vol. 14, Issue 9, pp. 1914-22, 1995 (PubMed).

Catalog No. ABIN967534
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