TEK Tyrosine Kinase, Endothelial (TEK) (Extracellular Domain) antibody

Details for Product No. ABIN967565
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Antigen
Synonyms TEK, DKFZp469E064, AA517024, Cd202b, Hyk, Tie2, tie-2, CD202B, TIE-2, TIE2, VMCM, VMCM1, Tie-2, tie2
Epitope
Extracellular Domain
(18), (17), (17), (16), (12), (11), (9), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(185), (122), (71), (66), (65), (48), (48), (1), (1)
Host
Mouse
(134), (51), (24), (5), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(19), (10), (8), (7), (5), (5), (5), (5), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
(113), (92), (59), (54), (26), (24), (12), (8), (7), (5), (4), (4), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN967565
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Immunogen Human TIE2 Recombinant Protein
Clone 4C6-1
Isotype IgG1
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name TIE2
Background The TIE receptor family is a member of the class of receptors called the receptor tyrosine kinases (RKT). RKTs are cell surface receptors which also contain a protein kinase domain in their intracellular portion and upon binding of their specific growth factor, initiate a series of downstream biological events. TIE receptors, designated Tie1 and Tie2 (Tek) have a tissue distribution which is limited primarily to cells of endothelial origin. Tie2 has been shown to be required for the normal development of vascular structures during embryogenesis. It has also been demonstrated to play a role in normal and pathological angiogenesis in adults. Tie2 has a predicted molecular weight of 126 kD, but may be observable at ~130-165 kDa. This antibody has been reported to recognize human and mouse Tie2 but not Tie1.
Molecular Weight 130-165 kDa
Research Area Organogenesis, Tyrosine Kinases
Comment

Related Products: ABIN967389, ABIN968537

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-TEK Tyrosine Kinase, Endothelial (TEK) (Extracellular Domain) antibody Western blot analysis for Tie2. Human endothelial cell lysates were probed with the mouse anti-Tie2 antibody at concentrations of 4 µg/mL (lane 1), 2 µg/mL (lane 2), and 1 µg/mL (lane 3). Due to glycosylation, Tie2 may be observable migrating in a range between ~130-165 kDa.
Product cited in: Dumont, Gradwohl, Fong et al.: "Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo." in: Genes & development, Vol. 8, Issue 16, pp. 1897-909, 1994 (PubMed).

Wong, Haroon, Werner et al.: "Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues." in: Circulation research, Vol. 81, Issue 4, pp. 567-74, 1997 (PubMed).

Peters, Coogan, Berry et al.: "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." in: British journal of cancer, Vol. 77, Issue 1, pp. 51-6, 1998 (PubMed).

Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999 (PubMed).

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