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TEK antibody (TEK Tyrosine Kinase, Endothelial) (Extracellular Domain)

Details for Product anti-TEK Antibody No. ABIN967565, Supplier: Login to see
Antigen
  • TEK
  • DKFZp469E064
  • AA517024
  • Cd202b
  • Hyk
  • Tie2
  • tie-2
  • CD202B
  • TIE-2
  • TIE2
  • VMCM
  • VMCM1
  • Tie-2
  • tie2
Alternatives
anti-Human TEK antibody for Immunohistochemistry (Frozen Sections)
Epitope
Extracellular Domain
30
23
22
20
17
13
12
10
8
7
6
6
5
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
251
125
72
6
3
3
2
2
1
Host
Mouse
180
73
24
5
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This TEK antibody is un-conjugated
19
14
12
8
7
7
6
5
4
4
4
4
4
4
3
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
149
124
60
46
44
25
20
15
10
9
6
6
4
4
3
1
1
Supplier
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Brand BD Pharmingen™
Immunogen Human TIE2 extracellular domain Recombinant Protein
Clone 33
Isotype IgG1, kappa
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name TIE2 (TEK Antibody Abstract)
Background The TIE receptor family is a member of the class of receptors called the receptor tyrosine kinases (RKT). RKTs are cell surface receptors which also contain a protein kinase domain in their intracellular portion and upon binding of their specific growth factor, initiate a series of downstream biological events. TIE receptors, designated Tie1 and Tie2 (Tek) have a tissue distribution which is limited primarily to cells of endothelial origin. Tie2 has been shown to be required for the normal development of vascular structures during embryogenesis. It has also been demonstrated to play a role in normal and pathological angiogenesis in adults. Tie2 has a predicted molecular weight of 126 kD, but may be observable at ~130-165 kDa. This antibody has been reported to recognize human and mouse Tie2 but not Tie1.
Molecular Weight 130-165 kDa
Research Area Organogenesis, Tyrosine Kinases
Pathways RTK Signaling
Comment

Related Products: ABIN967389, ABIN968537

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-TEK antibody (TEK Tyrosine Kinase, Endothelial) (Extracellular Domain) (ABIN967565) Western blot analysis for Tie2. Human endothelial cell lysates were probed with the m...
Product cited in: Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999 (PubMed).

Peters, Coogan, Berry et al.: "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." in: British journal of cancer, Vol. 77, Issue 1, pp. 51-6, 1998 (PubMed).

Wong, Haroon, Werner et al.: "Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues." in: Circulation research, Vol. 81, Issue 4, pp. 567-74, 1997 (PubMed).

Dumont, Gradwohl, Fong et al.: "Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo." in: Genes & development, Vol. 8, Issue 16, pp. 1897-909, 1994 (PubMed).