You are viewing an incomplete version of our website. Please click to reload the website as full version.

RIPK1 antibody (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1) (AA 385-650)

Details for Product anti-RIPK1 Antibody No. ABIN967985, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms C9orf12, RGD1311271, rIpk1, RIP, RIP1, D330015H01Rik, Rinp, Rip1, 2400006N03Rik, RP23-83I13.5, Rip
Show less
AA 385-650
(30), (15), (8), (7), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(114), (31), (31), (5), (2), (1)
(86), (24), (4)
Clonality (Clone)
Monoclonal ()
This RIPK1 antibody is un-conjugated
(4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(92), (37), (36), (23), (20), (12), (5), (2), (2), (1)
Pubmed 5 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 150 μg
Shipping to United States ( )
Immunogen Human RIP aa. 385-650
Clone 38-RIP
Isotype IgG2a
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name RIP (RIPK1 Antibody Abstract)
Background Binding or cross linking of the Fas antigen (also known as APO-1 and CD95) is known to elicit apoptosis in susceptible cells. Fas is a member of a family of cell surface receptors which includes tumor necrosis factor receptors (TNF-R, and TNF-R2) and nerve growth factor receptors (NGF-R), CD40, OX40, CD30, CD27, and 4-1BB. Several members of this family have been shown to regulate or induce cell death (TNF-R1 and TNF-R2). A 74 kDa member of this family protein named RIP (Receptor Interacting Protein) contains an N-terminal region with homology to protein kinases and a C-terminal region containing a cytoplasmic death domain present in both Fas and TNF-R1. Both Fas and RIP have been shown to require this death domain to induce apoptosis and overexpression of RIP has been shown to induce cell death in transfected cells.
Synonyms: Receptor Interacting Protein
Molecular Weight 74 kDa
Research Area Cancer, Apoptosis/Necrosis
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-RIPK1 antibody (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1) (AA 385-650) (ABIN967985) Western blot analysis of RIP on a human endothelial cell lysate. Lane 1: 1:1000, lane...
Immunofluorescence (IF) image for anti-RIPK1 antibody (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1) (AA 385-650) (ABIN967985) Immunofluorescence staining of WI-38 cells (Human lung fibroblasts, ATCC CCL-75).
 image for anti-RIPK1 antibody (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1) (AA 385-650) (ABIN967985) anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 385-650) antibody (Image 3)
Product cited in: Devin, Lin, Yamaoka et al.: "The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF." in: Molecular and cellular biology, Vol. 21, Issue 12, pp. 3986-94, 2001 (PubMed).

Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." in: Cancer research, Vol. 60, Issue 14, pp. 3947-56, 2000 (PubMed).

Lewis, Devin, Miller et al.: "Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation." in: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10519-26, 2000 (PubMed).

Stanger, Leder, Lee et al.: "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death." in: Cell, Vol. 81, Issue 4, pp. 513-23, 1995 (PubMed).

Takahashi, Tanaka, Brannan et al.: "Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand." in: Cell, Vol. 76, Issue 6, pp. 969-76, 1994 (PubMed).

Catalog No. ABIN967985
Contact our Customer Service for availability and price in your country.

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)