RIPK1 antibody (AA 131-277)

Catalog No. ABIN7193406

The Mouse Monoclonal anti-RIPK1 antibody (Clone 3B5B6) (ABIN7193406) specifically detects RIPK1 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for RIPK1 antibody (AA 131-277) (ABIN7193406)

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RIPK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 3B5B6

Product Details anti-RIPK1 Antibody

Binding Specificity: AA 131-277

Purpose: RIPK1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human RIPK1 (AA: 131-277) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for RIPK1

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Alternative Name: RIPK1

Background:

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

Molecular Weight: 76 kDa

Gene ID: 8737

UniProt: Q13546

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway