SCARB1 antibody (AA 104-294)

Catalog No. ABIN968230

This Mouse Monoclonal antibody specifically detects SCARB1 in WB and IF. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for SCARB1 antibody (AA 104-294) (ABIN968230)

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SCARB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 25-CLA

Product Details anti-SCARB1 Antibody

Binding Specificity: AA 104-294

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human CLA-1 aa. 104-294

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-SCARB1 antibody (ABIN968230)

Lasley, Narayan, Uittenbogaard, Smart: "Activated cardiac adenosine A(1) receptors translocate out of caveolae." in: The Journal of biological chemistry, Vol. 275, Issue 6, pp. 4417-21, (2000) (PubMed).

Kozarsky, Donahee, Rigotti, Iqbal, Edelman, Krieger: "Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels." in: Nature, Vol. 387, Issue 6631, pp. 414-7, (1997) (PubMed).

Acton, Rigotti, Landschulz, Xu, Hobbs, Krieger: "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5248, pp. 518-20, (1996) (PubMed).

Calvo, Vega: "Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18929-35, (1993) (PubMed).

Target Details for SCARB1

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Alternative Name: CLA-1

Background: CLA-1 (CD36 and LIMPII Analogous-1) is member of a novel gene family that includes CD36, LIMPII, and SR-BI. CD36 is a cell surface glycoprotein that binds to collagen type I and thrombospondin. LIMPII (lysosomal integral membrane protein II), as its name suggests, is expressed on the membrane of lysosomes. SR-BI (scavenger receptor type B class I) is involved in the selective uptake of cholesterol esters. These proteins include two membrane-anchoring regions, two short cytoplasmic tails, and a large extracellular/luminal domain. CLA-1 mRNA is detected in a wide range of tissues including adrenal glands, liver, and testis. Its expression and similarity with other family members suggest it may play a role in HDL metabolism. However, identification of the CLA-1 receptor on monocytes indicates additional CLA-1 functions in leukocytes.
Synonyms: CD36 and LIMPII Analogous-1

Molecular Weight: 80 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interactome