General Transcription Factor III (GTF2I) (AA 17-123) antibody

Details for Product No. ABIN968264
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Antigen
Synonyms bap-135, bap135, btkap1, diws, gtfii-i, ib291, spin, tfii-i, wbs, wbscr6, 6030441I21Rik, BAP-135, GtfII-I, Spin, TFII-I, WBSCR6, Gtf2ird1, BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, WBS
Epitope
AA 17-123
(12), (12), (8), (7), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(77), (25), (22), (3), (2), (2)
Host
Mouse
(61), (16)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(61), (34), (22), (14), (13), (10), (4), (4), (3), (3), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN968264
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Immunogen Human BAP-135
Clone BF12
Isotype IgG1
Cross-Reactivity Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name TFII-I
Background General transcription factor II-I (GTF2I/TFII-I/SPIN/BAP-135) is a transcription factor that contains six directly repeated 90-residue regions, which possess helix-loop-helix protein-protein interaction motifs. TFII-I can regulate transcription in T-cells through interaction with the initiator elments (Inrs) within the AdML and Vbeta promoters, and associates with HIV-1, TdT, and ribonucleotide reductase R1 Inrs. In addition, TFII-I associates with the E box motif, the CACGTG sequence, and with serum response element sequences. The helix-loop-helix repeats facilitate TFII-I interaction with other transcription factors, such as USF, Myc, Phox 1, MADS box protein serum response factor, and STATs. TFII-I was also identified as Bruton's tyrosine kinase (btk)-associated protein (BAP-135). TFII-I/BAP-135 is tyrosine phosphorylated by btk and after EGF stimulation, and this phosphorylation enhances TFII-I transcriptional activity. The wide expression of TFII-I and the interaction of TFII-I with various Inrs and transcription factors implicates TFII-I in various signaling pathways that regulate gene transcription.
Synonyms: BAP-135
Molecular Weight 135/140 kDa
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-General Transcription Factor III (GTF2I) (AA 17-123) antibody Immunofluorescent staining of FHS cells.
anti-General Transcription Factor III (GTF2I) (AA 17-123) antibody (2) Western blot analysis of TFII-I on HeLa cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of anti-TFII-I.
anti-General Transcription Factor III (GTF2I) (AA 17-123) antibody (3) anti-General Transcription Factor III (GTF2I) (AA 17-123) antibody (Image 3)
Product cited in: Yang, Desiderio: "BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 2, pp. 604-9, 1997 (PubMed).

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