Sorting Nexin 1 (SNX1) (AA 1-108) antibody

Details for Product No. ABIN968558
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Antigen
Synonyms d254, sb:cb923, snx1, wu:fb40c08, wu:fj65g09, MGC82200, SNX1, HsT17379, VPS5, ARABIDOPSIS THALIANA SORTING NEXIN 1, ATSNX1, K16F4.11, K16F4_11, sorting nexin 1
Epitope
AA 1-108
(12), (7), (7), (6), (4), (3), (2), (2)
Reactivity
Human
(56), (26), (20), (13), (12), (12), (1)
Host
Mouse
(38), (15), (6), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(47), (32), (10), (10), (9), (6), (5), (3), (2), (1)
Pubmed 4 references available
Quantity 50 µg
Options
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Catalog No. ABIN968558
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Immunogen Human SNX1
Clone CB11
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SNX1
Background Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors. A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling downstream of receptors. The sorting nexins (SNX1, SNX1A, SNX2, SNX3, and SNX4) are a family of intracellular proteins that are thought to direct the sorting of receptor proteins. The SNX proteins contain a conserved 100 amino acid region termed the phox homology (PX) domain and are part of a family of hydrophilic proteins which includes S. cerevisiae proteins that function in protein sorting. SNX1, SNX2, and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. SNX1 directs the EGF receptor to the lysosomes for degradation. SNX2 forms homomeric complexes and heteromeric complexes with SNX1, SNX1A, and SNX4. These complexes are thought to be necessary for efficient protein sorting. Thus, SNX1 and other sorting nexins are thought to play important roles in the specificity of protein trafficking to and from the plasma membrane.
Molecular Weight 74 kDa
Research Area Signaling, Transporters
Comment

Related Products: ABIN967389, ABIN968535

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Sorting Nexin 1 (SNX1) (AA 1-108) antibody Immunofluorescence staining of HeLa cells.
anti-Sorting Nexin 1 (SNX1) (AA 1-108) antibody (2) Western blot analysis of SNX1 on HeLa lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of SNX1.
anti-Sorting Nexin 1 (SNX1) (AA 1-108) antibody (3) anti-Sorting Nexin 1 (SNX1) (AA 1-108) antibody (Image 3)
Product cited in: Kurten, Cadena, Gill: "Enhanced degradation of EGF receptors by a sorting nexin, SNX1." in: Science (New York, N.Y.), Vol. 272, Issue 5264, pp. 1008-10, 1996 (PubMed).

Haft, de la Luz Sierra, Barr et al.: "Identification of a family of sorting nexin molecules and characterization of their association with receptors." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7278-87, 1998 (PubMed).

Strehlow, Jelaska, Strehlow et al.: "A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma." in: The Journal of clinical investigation, Vol. 103, Issue 8, pp. 1179-90, 1999 (PubMed).

Cozier, Carlton, McGregor et al.: "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48730-6, 2002 (PubMed).

Validation Images
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