MPDZ antibody (AA 65-247)

Catalog No. ABIN968588

The Mouse Monoclonal anti-MPDZ antibody has been validated for WB and IF. It is suitable to detect MPDZ in samples from Mouse and Rat. There are 2+ publications available.

Quick Overview for MPDZ antibody (AA 65-247) (ABIN968588)

Target: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Reactivity: Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MPDZ antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 43-MUPP1

Product Details anti-MPDZ Antibody

Binding Specificity: AA 65-247

Cross-Reactivity: Mouse (Murine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat MUPP1 aa. 65-247

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN967389, ABIN968545

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-MPDZ antibody (ABIN968588)

Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

Ullmer, Schmuck, Figge, Lübbert: "Cloning and characterization of MUPP1, a novel PDZ domain protein." in: FEBS letters, Vol. 424, Issue 1-2, pp. 63-8, (1998) (PubMed).

Target Details for MPDZ

Target: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Alternative Name: MUPP1

Background: The postsynaptic density protein PSD-95 interacts with the cytoplasmic tail of ion channel subunits via a protein-protein motif called the PDZ domain. PSD-95 belongs to a family of PDZ domain-containing proteins that includes SAP97/Dlg, PSD-93/chapsyn-110, and SAP102. These proteins are characterized by three PDZ domains in the N-terminal half and an SH3 and guanylate kinase-like domain in the C-terminal region. They may be involved in the localization and clustering of ion channels and receptors at synaptic sites. Other PDZ domain-containing proteins such as glutamate receptor interacting protein (GRIP), Homer, and multi-PDZ-domain protein (MUPP1) do not contain guanylate kinase-like domains, but have also been implicated in receptor localization. MUPP1 contains thirteen PDZ domains and is expressed in human heart, brain, placenta, liver, skeletal muscle, kidney, and pancreas. In addition, smaller variants of MUPP1 are expressed in heart, liver, kidney, and brain. The C-terminal region of the 5-HT2c receptor interacts with MUPP1, suggesting that MUPP1 may have important protein-protein interactions during G-protein coupled receptor signaling.

Molecular Weight: 219 kDa

Pathways: Synaptic Membrane, Phototransduction