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Details for Product No. ABIN968679

Cullin 3 (CUL3) (AA 565) antibody

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Antigen
Synonyms CUL-3, PHA2E, AI467304, AW146203, mKIAA0617, Cullin-3, CUL-3-A, Cullin-3-A, cul3, cul3a, CUL-3-B, Cullin-3-B, cul3b, wu:fc37e01, CUL3, ATCUL3, ATCUL3A, CUL3A, T24P13.25, cullin 3, cullin 3A
Epitope
»Alternatives AA 565
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN968679
Quantity 50 µg
Price
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Immunogen Human CUL-3
Clone 3
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CUL-3
Background The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes. Abnormal nuclear localization of Cul-2 is seen in a rare hereditary condition known as VHL (von Hippel-Lindau) syndrome. Patients with VHL syndrome possess a mutant VHL gene and develop cancers such as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas. Cul-3 is widely expressed in normal cells and tissues, and shows increased expression in colon cancer cells. Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination, while deletion of Cul-3 in mice leads to increased cyclin E accumulation and abnormal regulation of S-phase. Thus, the Cul family of proteins may have roles in cell cycle regulation and tumoriogenesis. This antibody is routinely tested by western blot analysis.
Molecular Weight 89 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Singer, Gurian-West, Clurman et al.: "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells." in: Genes & development, Vol. 13, Issue 18, pp. 2375-87, 1999 (PubMed).

Hori, Osaka, Chiba et al.: "Covalent modification of all members of human cullin family proteins by NEDD8." in: Oncogene, Vol. 18, Issue 48, pp. 6829-34, 2000 (PubMed).

Alternatives for antigen "Cullin 3 (CUL3)", type "Antibodies"
Hosts (57), (6)
Reactivities (63), (30), (21), (12), (12), (12), (12)
Applications (42), (24), (21), (16), (13), (10), (7), (5), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (5), (2), (2), (1), (1), (1), (1), (1)
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