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Details for Product No. ABIN968794

Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 199-298) antibody

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Synonyms ICBP90, Np95, RNF106, hNP95, hUHRF1, AL022808, NP95, fb97f09, zgc:63539, wu:fb97f09, UHRF1
»Alternatives AA 199-298
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN968794
Quantity 50 µg
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Immunogen Human ICBP90
Clone MOC-31
Isotype IgG2a
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name ICBP90
Background DNA topoisomerases are ubiquitous nuclear enzymes that alter the topology of DNA. Topoisomerase I produces transient single-stranded breaks in DNA, while topoisomerase II produces transient double-stranded breaks in DNA. These DNA breaks are important for DNA replication and chromosome condensation and segregation. Two types of topoisomerase II have been identified, TopoIIalpha and TopoIIbeta. During interphase, TopoIIalpha is found in the nucleoplasm and nucleoli, and in mitosis, TopoIIalpha is found associated with metaphase chromosomes and centromeres. Transcriptional control of TopoIIalpha expression is regulated through multiple gene promoters, which include five inverted CCAAT boxes, one ATF binding sequence, and two GC-rich boxes. ICBP90 was identified in one-hybrid screen of proteins that can bind an inverted CCAAT box. ICBP90 is expressed highest in proliferative tissues such as thymus, liver, and bone marrow. Overexpression of ICBP90 in COS-1-transfected cells leads to enhanced expression of TopoIIalpha. ICBP90 co-localizes with TopoIIalpha in proliferating areas of appendix and in high grade breast carcinomas. Thus, ICBP90 may be an important transcripitonal regulator of TopoIIalpha expression in proliferating cells.
Molecular Weight 97 kDa
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Hopfner, Mousli, Jeltsch et al.: "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression." in: Cancer research, Vol. 60, Issue 1, pp. 121-8, 2000 (PubMed).

Hopfner, Mousli, Garnier et al.: "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression." in: Gene, Vol. 266, Issue 1-2, pp. 15-23, 2001 (PubMed).

Alternatives for antigen "Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1)", type "Antibodies"
Hosts (27), (15), (1), (1)
Reactivities (41), (14), (12), (11), (11), (11), (11), (3), (1)
Applications (35), (16), (15), (9), (6), (6), (4), (4), (4), (4)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (2), (2), (1), (1), (1)