UHRF1 antibody (AA 616-755)

Catalog No. ABIN5542544

Product Details anti-UHRF1 Antibody

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Binding Specificity: AA 616-755

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This UHRF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human UHRF1 (AA: 616-755) expressed in E. coli.

Clone: 2A8C7

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: , FCM:

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for UHRF1

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Alternative Name: UHRF1 (UHRF1 Products)

Synonyms: ICBP90 antibody, Np95 antibody, RNF106 antibody, hNP95 antibody, hUHRF1 antibody, AL022808 antibody, NP95 antibody, fb97f09 antibody, wu:fb97f09 antibody, zgc:63539 antibody, UHRF1 antibody, ubiquitin like with PHD and ring finger domains 1 antibody, ubiquitin-like, containing PHD and RING finger domains, 1 antibody, ubiquitin-like with PHD and ring finger domains 1 antibody, UHRF1 antibody, Uhrf1 antibody, uhrf1 antibody

Background:

Description: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.,

Aliases: Np95, hNP95, ICBP90, RNF106, TDRD22, hUHRF1, huNp95

Molecular Weight: 89.8 kDa

Gene ID: 29128

HGNC: 5335