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Hemochromatosis (HFE) antibody

Details for Product No. ABIN969192, Supplier: Login to see
Antigen
  • HFE1
  • HH
  • HLA-H
  • MVCD7
  • TFQTL2
  • MR2
Reactivity
Human
62
20
16
1
Host
Mouse
52
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
50
21
13
13
11
6
4
3
1
1
Supplier
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Immunogen Purified recombinant fragment of human HFE expressed in E. coli.
Clone 3F1
Isotype IgG1
Purification Ascites
Alternative Name HFE (HFE Antibody Abstract)
Background The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
Molecular Weight 40 kDa
Gene ID 3077
HGNC 3077
Research Area Stem Cells, Hematopoietic Progenitors, Metabolism
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
ELISA image for anti-Hemochromatosis (HFE) antibody (ABIN969192) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunocytochemistry (ICC) image for anti-Hemochromatosis (HFE) antibody (ABIN969192) Figure 2: Immunofluorescence analysis of HepG2 cells using HFE mouse mAb (green) . Bl...
Western Blotting (WB) image for anti-Hemochromatosis (HFE) antibody (ABIN969192) Figure 3: Western blot analysis using HFE mAb against human HFE (AA: 125-282) recombi...
Western Blotting (WB) image for anti-Hemochromatosis (HFE) antibody (ABIN969192) Figure 4: Western blot analysis using HFE mAb against HEK293 (1) and HFE (AA: 125-282...
Product cited in: Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

Valenti, Girelli, Valenti et al.: "HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 4, Issue 8, pp. 1331-7, 2009 (PubMed).