Hemochromatosis (HFE) antibody

Details for Product No. ABIN969192
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Antigen
Synonyms HFE1, HH, HLA-H, MVCD7, TFQTL2, MR2
Reactivity
Human
(42), (22), (20), (18), (17)
Host
Mouse
(35), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(29), (17), (13), (10), (8), (6), (4), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN969192
Quantity 100 µL
Price
396.00 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human HFE expressed in E. coli.
Clone 3F1
Isotype IgG1
Purification Ascites
Alternative Name HFE
Background Synonyms:
HH, HFE1, HLA-H, MVCD7, TFQTL2, MGC103790, dJ221C16. 10. 1
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with β2-microglobulin (β2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
Molecular Weight 40 kDa
Gene ID 3077
Research Area Stem Cells, Hematopoietic Progenitors, Metabolism
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Hemochromatosis (HFE) antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-Hemochromatosis (HFE) antibody (2) Figure 3: Immunofluorescence analysis of HepG2 cells using HFE mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye.
anti-Hemochromatosis (HFE) antibody (3) Figure 1: Western blot analysis using HFE mAb against human HFE (AA: 125-282) recombinant protein. (Expected MW is 44 kDa)
anti-Hemochromatosis (HFE) antibody (4) Figure 2: Western blot analysis using HFE mAb against HEK293 (1) and HFE (AA: 125-282) -hIgGFc transfected HEK293 (2) cell lysate.
Product cited in: Valenti, Girelli, Valenti et al.: "HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 4, Issue 8, pp. 1331-7, 2009 (PubMed).

Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

Hosts (35), (9)
Reactivities (42), (22), (20), (18), (17)
Applications (29), (17), (13), (10), (8), (6), (4), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (1), (1), (1), (1)
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