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Details for Product No. ABIN969573

Ubiquitin B (UBB) antibody

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Antigen
Synonyms Ubc, Ubb2, Uba52, Rps27a, AL033289, UBC, UBB, Ubiquitin
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Fluorescence Microscopy (FM)
Pubmed 2 references available
Catalog no. ABIN969573
Quantity 0.1 mg
Price
396.00 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human UBB expressed in E. coli.
Clone 3C12
Isotype IgG1
Purification Purified
Alternative Name UBB
Background Synonyms:
UBC, UBA52, RPS27A
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final AA after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
Molecular Weight 26 kDa
Gene ID 7314
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Choudhary, Kumar, Gnad et al.: "Lysine acetylation targets protein complexes and co-regulates major cellular functions." in: Science (New York, N.Y.), Vol. 325, Issue 5942, pp. 834-40, 2009 (PubMed).

Komander: "The emerging complexity of protein ubiquitination." in: Biochemical Society transactions, Vol. 37, Issue Pt 5, pp. 937-53, 2009 (PubMed).

Alternatives for antigen "Ubiquitin B (UBB)", type "Antibodies"
Hosts (14), (2)
Reactivities (14), (13), (11), (8)
Applications (10), (6), (5), (3), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1)
Epitopes (2)
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