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Browse our FADD Proteins (FADD)

Full name:
Fas (TNFRSF6)-Associated Via Death Domain Proteins (FADD)
On www.antibodies-online.com are 13 Fas (TNFRSF6)-Associated Via Death Domain (FADD) Proteins from 7 different suppliers available. Additionally we are shipping FADD Antibodies (264) and FADD Kits (13) and many more products for this protein. A total of 315 FADD products are currently listed.
Synonyms:
Mort1, Mort1/FADD, TNFRSF6
list all proteins Gene Name GeneID UniProt
FADD 8772 Q13158
FADD 14082 Q61160
Rat FADD FADD 266610  

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FADD Proteins (FADD) by Origin

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Top referenced FADD Proteins

  1. Human FADD Protein expressed in Escherichia coli (E. coli) - ABIN667076 : Tourneur, Buzyn, Chiocchia: FADD adaptor in cancer. in Medical immunology (London, England) 2005 (PubMed)
    Show all 2 references for ABIN667076

  2. Human FADD Protein expressed in Wheat germ - ABIN1353355 : García-Fuster, Ramos-Miguel, Miralles, García-Sevilla et al.: Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ... in Neuropharmacology 2008 (PubMed)

More Proteins for FADD Interaction Partners

Human Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. This study reveals an essential role of SUMOylated FADD in Drp1 (show CRMP1 Proteins)- and caspase-10 (show CASP10 Proteins)-dependent necrosis.

  2. In myelodysplastic syndrome, FADD expression is regulated by SPAG6 (show SPAG6 Proteins) which influences its interaction with TRAIL death receptors.

  3. High levels of FADD and caspase-8 (show CASP8 Proteins), but not caspase-3 (show CASP3 Proteins), were associated with increased incidence of coronary events in subjects from the general population.

  4. Both Fas associated via death domain gene copy number amplification and high protein expression were significantly associated with lymph node metastasis and had the shortest disease-free survival and overall survival.

  5. FADD, as well as NEMO, is a substrate for LUBAC ubiquitin ligase (E3) complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits.

  6. autoinflammation-associated H443P nlrc4 (show NLRC4 Proteins) mutant is altered in interaction with SUG1 (show PSMC5 Proteins) and ubiquitinated proteins, triggering constitutive caspase-8 (show CASP8 Proteins)-mediated cell death dependent on FADD but independent of Ser (show SIGLEC1 Proteins)(533) phosphorylation.

  7. this study shows that C5a signaling induces apoptosis in brain vascular endothelial cells in experimental lupus through activation of FADD

  8. Authors identify non-canonical nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) signaling up regulated and it was directly linked with the tumor necrosis with MT2A (show MT2 Proteins) and pFADD genes. pFADD with MT2A (show MT2 Proteins) can inhibit the apoptosis and promote proliferation, of colorectal cancer cells.

  9. knockdown of cFLIPL and induced expression of FADD rapidly accumulate intracellular ROS (show ROS1 Proteins) accompanied by JNK1 (show MAPK8 Proteins) activation to substantiate apoptosis.

  10. Data indicate that FADD mediated apoptotic cell death was directed by ubiquitination of cFLIPL and inhibition of NF-kappaB (show NFKB1 Proteins) activation.

Mouse (Murine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. This study reveals an essential role of SUMOylated FADD in Drp1 (show CRMP1 Proteins)- and caspase-10 (show CASP10 Proteins)-dependent necrosis.

  2. knockdown of cFLIPL and induced expression of FADD rapidly accumulate intracellular ROS (show ROS1 Proteins) accompanied by JNK1 (show MAPK8 Proteins) activation to substantiate apoptosis.

  3. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  4. Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88 (show MYD88 Proteins)-dependent systemic inflammation.

  5. A constitutively phosphoryl-mimicking mutation of Fas (show FAS Proteins)-associated death domain (FADD-D) enhances Notch-1 (show NOTCH1 Proteins) signaling and compromises Wnt (show WNT2 Proteins) signaling in both cultured myoblasts and regenerating muscles.

  6. Beta amyloid-induced upregulation of death receptor 6 (show TNFRSF21 Proteins) accelerates the toxic effect of N-terminal fragment of amyloid precursor protein (show APP Proteins)

  7. Phosphorylation of FADD by the kinase CK1alpha (show CSNK1A1 Proteins) promotes KRASG12D-induced lung cancer.

  8. This study evaluated the role of FADD in pancreatic islets and insulin (show INS Proteins) secretion.

  9. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  10. These data suggest that as a death receptor, FADD is also required for cell survival in beta-selection as a regulator of Notch1 (show NOTCH1 Proteins) expression.

Pig (Porcine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. FADD induces apoptosis

Cow (Bovine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. mapping and sequencing of bovine FADD cDNA, and characterization of its expression in endothelial cells

FADD Protein Profile

Protein Summary

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Alternative names and synonyms associated with FADD

  • Fas (TNFRSF6)-associated via death domain (FADD)
  • Fas (TNFRSF6)-associated via death domain (Fadd)
  • Mort1 protein
  • Mort1/FADD protein
  • TNFRSF6 protein

Protein level used designations for FADD

Fas-associating death domain-containing protein , Fas-associating protein with death domain , growth-inhibiting gene 3 protein , mediator of receptor induced toxicity , mediator of receptor-induced toxicity , protein FADD , FAS-associated death domain protein , FAS-associating death domain-containing protein , Fas (TNF receptor superfamily, member 6) , Fas-associated via death domain

GENE ID SPECIES
8772 Homo sapiens
14082 Mus musculus
266610 Rattus norvegicus
595129 Sus scrofa
493720 Bos taurus
611694 Canis lupus familiaris
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