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Browse our FADD Proteins (FADD)

Full name:
Fas (TNFRSF6)-Associated Via Death Domain Proteins (FADD)
On are 14 Fas (TNFRSF6)-Associated Via Death Domain (FADD) Proteins from 8 different suppliers available. Additionally we are shipping FADD Antibodies (220) and FADD Kits (12) and many more products for this protein. A total of 272 FADD products are currently listed.
Mort1, Mort1/FADD, TNFRSF6
list all proteins Gene Name GeneID UniProt
FADD 8772 Q13158
FADD 14082 Q61160
Rat FADD FADD 266610  

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FADD Proteins (FADD) by Origin

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Top referenced FADD Proteins

  1. Human FADD Protein expressed in Escherichia coli (E. coli) - ABIN667076 : Tourneur, Buzyn, Chiocchia: FADD adaptor in cancer. in Medical immunology (London, England) 2005 (PubMed)
    Show all 2 references for ABIN667076

  2. Human FADD Protein expressed in Wheat germ - ABIN1353355 : García-Fuster, Ramos-Miguel, Miralles, García-Sevilla et al.: Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ... in Neuropharmacology 2008 (PubMed)

More Proteins for FADD Interaction Partners

Human Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  2. TCGA analysis showed that ANO1 and FADD, located at 11q13, were co-expressed at transcript level and significantly associated with overall and disease-free survival

  3. Data (including data obtained in transgenic mice) suggest FADD is key in genesis of neural tube defects in pups of diabetic mice; unfolded protein response/endoplasmic reticulum stress was prevented by over-expression of human dominant negative FADD.

  4. multifaceted kinase, CK2, phosphorylates FADD and is involved in its sub-cellular localization.

  5. domains of calmodulin (show CALM1 Proteins) mediate FADD and TRADD (show TRADD Proteins) interaction

  6. The gene expression analysis showed statistically significant difference between cases and healthy controls for both FADD (p<0.02) and FAS (show FAS Proteins) (p<0.007) genes

  7. Observed upregulation of cortical p-194 FADD and p-FADD/FADD ratio (higher pro-survival index) in major depression; could play a major role to counteract the known activation of the intrinsic (mitochondrial) apoptotic pathway in the brain

  8. FADD death effector domain and c-FLIP (show CFLAR Proteins) death effector domain structures, the binding activity of FADD DED (show AATF Proteins) to the c-FLIP (show CFLAR Proteins) death effector domains, and the protein-protein interactions involving the regulation of both apoptosis and necrosis.

  9. The genotype of the promoter SNP (rs10898853) of FADD was found to be significantly associated with papillary thyroid cancer in a South Korean case control study.

  10. These results indicate that FADD, as a host pro-apoptotic protein, plays important roles in regulating HIV-1 replication and production in several ways, and apoptotic pathway inhibition is able to decrease HIV-1 replication and production

Mouse (Murine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  2. Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88 (show MYD88 Proteins)-dependent systemic inflammation.

  3. A constitutively phosphoryl-mimicking mutation of Fas (show FAS Proteins)-associated death domain (FADD-D) enhances Notch-1 (show NOTCH1 Proteins) signaling and compromises Wnt (show WNT2 Proteins) signaling in both cultured myoblasts and regenerating muscles.

  4. Beta amyloid-induced upregulation of death receptor 6 (show TNFRSF21 Proteins) accelerates the toxic effect of N-terminal fragment of amyloid precursor protein (show APP Proteins)

  5. Phosphorylation of FADD by the kinase CK1alpha (show CSNK1A1 Proteins) promotes KRASG12D-induced lung cancer.

  6. This study evaluated the role of FADD in pancreatic islets and insulin (show INS Proteins) secretion.

  7. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  8. These data suggest that as a death receptor, FADD is also required for cell survival in beta-selection as a regulator of Notch1 (show NOTCH1 Proteins) expression.

  9. using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis and reduced cell numbers, which may be attributed to the reduction of Glut1 (show SLC2A1 Proteins) expression and correspondingly decreased glucose uptake

  10. RIPK1 (show RIPK1 Proteins), FADD, and caspase-8 (show CASP8 Proteins) are required for YopJ-induced cell death and caspase-1 (show CASP1 Proteins) activation

Pig (Porcine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. FADD induces apoptosis

Cow (Bovine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. mapping and sequencing of bovine FADD cDNA, and characterization of its expression in endothelial cells

FADD Protein Profile

Protein Summary

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Alternative names and synonyms associated with FADD

  • Fas (TNFRSF6)-associated via death domain (FADD)
  • Fas (TNFRSF6)-associated via death domain (Fadd)
  • Mort1 protein
  • Mort1/FADD protein
  • TNFRSF6 protein

Protein level used designations for FADD

Fas-associating death domain-containing protein , Fas-associating protein with death domain , growth-inhibiting gene 3 protein , mediator of receptor induced toxicity , mediator of receptor-induced toxicity , protein FADD , FAS-associated death domain protein , FAS-associating death domain-containing protein , Fas (TNF receptor superfamily, member 6) , Fas-associated via death domain

8772 Homo sapiens
14082 Mus musculus
266610 Rattus norvegicus
595129 Sus scrofa
493720 Bos taurus
611694 Canis lupus familiaris
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