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anti-Human ICAM5 Antibodies:
anti-Mouse (Murine) ICAM5 Antibodies:
anti-Rat (Rattus) ICAM5 Antibodies:
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Cow (Bovine) Polyclonal ICAM5 Primary Antibody for WB - ABIN2782226
Tian, Lappalainen, Autero, Hänninen, Rauvala, Gahmberg: Shedded neuronal ICAM-5 suppresses T-cell activation. in Blood 2008
Human Polyclonal ICAM5 Primary Antibody for IHC, ELISA - ABIN185736
Yoshihara, Oka, Nemoto, Watanabe, Nagata, Kagamiyama, Mori: An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. in Neuron 1994
These findings suggested that Talin-1 (show TLN1 Antibodies) protein was significantly upregulated in PCa (show FLVCR1 Antibodies) tissues compared with that of BPH (show GLI3 Antibodies) tissue and Talin-1 (show TLN1 Antibodies) expression was an independent predictor for lymph node metastasis and biochemical recurrence of PCa (show FLVCR1 Antibodies).
Serum talin-1 (show TLN1 Antibodies) had 97.7% sensitivity.
Both TLN-1 (show TLN1 Antibodies) and TLN-2 (show TLN2 Antibodies) levels correlate with tumorigenicity in human HCC (show FAM126A Antibodies), indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .
TLN1 (show TLN1 Antibodies) significantly increases in refractory glioblastoma multiforme
Applying correlative imaging to link live cell and fixed immunofluorescence data on a single cell basis, we related per cell talin-1 (show TLN1 Antibodies) levels to per cell measures quantitatively defining an array of cellular properties.
Disruption of the RIAM (show APBB1IP Antibodies)/lamellipodin (show RAPH1 Antibodies)-integrin-talin complex markedly impairs cell migration.
Our data demonstrate that high expression of Talin-1 (show TLN1 Antibodies) is associated with significantly poorer OS and poorer DMFS in NPC (show NPC1 Antibodies) and depletion of Talin-1 (show TLN1 Antibodies) expression inhibited NPC (show NPC1 Antibodies) cell migration and invasion. Talin-1 (show TLN1 Antibodies) may serve as novel prognostic biomarker in NPC (show NPC1 Antibodies).
The activation of vinculin (show VCL Antibodies) by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin (show VCL Antibodies) association.
Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb (show ITGA2B Antibodies)/GPIIIa (show ITGB3 Antibodies) complex transmembrane/C-terminal domains and talin-1 (show TLN1 Antibodies) in cell membrane environment during platelet activation.
Data suggest that anionic lipids (such as phosphatidylinositol phosphates) play crucial role in localization of peripheral membrane proteins (such as TLN1 (show TLN1 Antibodies), auxilin (show DNAJC6 Antibodies)-1, and PTEN (show PTEN Antibodies) [phosphatase and tensin homolog (show PTEN Antibodies)]). [review-like article]
These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (show FN1 Antibodies) binding and adhesion.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb (show LHB Antibodies)), follicle stimulating hormone beta (Fshb (show FSHB Antibodies)), and intracellular adhesion molecule (show NCAM1 Antibodies)-5 (Icam5) in females but only decreased expression of Icam5 in males.
Binding of vinculin (show VCL Antibodies) to the R1-R3 region of the talin rod is important for focal adhesion stability.
Data indicate that talin mechanics are isoform specific so that expression of either talin-1 (show TLN1 Antibodies) or talin-2 (show TLN2 Antibodies) modulates extracellular rigidity sensing.
Conformational activation of talin by PREL-1 (show APBB1IP Antibodies) triggers integrin-mediated cell adhesion.
Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures.
This study revealed a similar expression of ICAM-5 in dendritic elements at P14 (show PCOLCE Antibodies) and P28 (show GSTO1 Antibodies); however, an increased prevalence of ICAM-5 was noted in dendritic protrusions at P28 (show GSTO1 Antibodies) in the MMP-9 (show MMP9 Antibodies) null animals
reduction of talin-beta3 integrin (show ITGB3 Antibodies) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
Results suggest that the interaction between ICAM-5 and beta1 integrins is important in formation of functional synapses.
As talin engages F-actin, force exerted on the R2R3 helical bundles disrupts RIAM (show APBB1IP Antibodies) binding and exposes the vinculin (show VCL Antibodies) binding sites, which recruit vinculin (show VCL Antibodies) to stabilize the complex.
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
intercellular adhesion molecule 5
, intercellular adhesion molecule 3