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Browse our anti-CDK4 (CDK4) Antibodies

Full name:
anti-Cyclin-Dependent Kinase 4 Antibodies (CDK4)
On are 309 Cyclin-Dependent Kinase 4 (CDK4) Antibodies from 30 different suppliers available. Additionally we are shipping CDK4 Proteins (39) and CDK4 Kits (30) and many more products for this protein. A total of 391 CDK4 products are currently listed.
8-6, cdk, cdk4, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726

Most Popular Reactivities for anti-CDK4 (CDK4) Antibodies

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anti-Human CDK4 Antibodies:

anti-Mouse (Murine) CDK4 Antibodies:

anti-Rat (Rattus) CDK4 Antibodies:

All available anti-CDK4 Antibodies

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Top referenced anti-CDK4 Antibodies

  1. Human Monoclonal CDK4 Primary Antibody for IHC (f), IF - ABIN967778 : Angus, Wheeler, Ranmal, Zhang, Markey, Mathews, Knudsen: Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN967778

  2. Human Polyclonal CDK4 Primary Antibody for EIA, IHC (p) - ABIN359662 : Mori, Yang, Kawamata, Miller, Mizoguchi, Koeffler: Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors. in International journal of hematology 2003 (PubMed)
    Show all 5 references for ABIN359662

  3. Human Monoclonal CDK4 Primary Antibody for IP, WB - ABIN967404 : Graña, Reddy: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). in Oncogene 1995 (PubMed)
    Show all 3 references for ABIN967404

  4. Dog (Canine) Monoclonal CDK4 Primary Antibody for BI, IHC (fro) - ABIN967650 : Depoortere, Van Keymeulen, Lukas, Costagliola, Bartkova, Dumont, Bartek, Roger, Dremier: A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes. in The Journal of cell biology 1998 (PubMed)
    Show all 3 references for ABIN967650

  5. Human Polyclonal CDK4 Primary Antibody for FACS, IF - ABIN391751 : Ramirez, Herbert, Vaughan, Zou, Gandia, Morales, Wright, Shay: Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. in Oncogene 2003 (PubMed)
    Show all 3 references for ABIN391751

  6. Human Monoclonal CDK4 Primary Antibody for IF, WB - ABIN1106647 : Demetrick, Zhang, Beach: Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. in Cytogenetics and cell genetics 1994 (PubMed)
    Show all 2 references for ABIN1106647

  7. Human Monoclonal CDK4 Primary Antibody for IHC (f), IP - ABIN967647 : Johnson, Walker: Cyclins and cell cycle checkpoints. in Annual review of pharmacology and toxicology 1999 (PubMed)
    Show all 2 references for ABIN967647

  8. Human Monoclonal CDK4 Primary Antibody for ICC, IF - ABIN267545 : Brookes, Gagrica, Sanij, Rowe, Gregory, Hara, Peters: Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. in Cell cycle (Georgetown, Tex.) 2015 (PubMed)

  9. Human Polyclonal CDK4 Primary Antibody for ICC, IF - ABIN441316 : Huang, Kao, Toh, Lin, Chou, Hu, Lu, Liou, Chao, Hour, Pu: UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity. in Biochemical pharmacology 2011 (PubMed)

  10. Cow (Bovine) Polyclonal CDK4 Primary Antibody for WB - ABIN2792086 : Elkahloun, Krizman, Wang, Hofmann, Roe, Meltzer: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. in Genomics 1997 (PubMed)

More Antibodies against CDK4 Interaction Partners

Zebrafish Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.

Human Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. miR1 (show FSD1 Antibodies) expression inversely correlated with MET, cyclin D1 (show CCND1 Antibodies) and CDK4 expression in esophageal squamous cell carcinoma cells.

  2. we illustrate that the miR (show MLXIP Antibodies)-124/CDK4 axis plays an important role in radiation sensitivity of human esophageal cancer cells by targeting CDK4.

  3. MiR-16 (show GDE1 Antibodies) upregulation could reduce CDK4 expression.

  4. both miR (show MLXIP Antibodies)-613 mimics and inhibitors could decrease and increase CDK4 protein levels in non-small cell lung cancer-derived cells, respectively.

  5. Upregulation of CDK4 expression is associated with gastric cancer.

  6. Our studies demonstrate that CDK4 and miR (show MLXIP Antibodies)-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma .

  7. miR (show MLXIP Antibodies)-539 plays an important role in the initiation and progression of nasopharyngeal carcinoma by targeting CDK4.

  8. The concept that cotargeting MEK and CDK4/6 would prove efficacious in KRAS-mutant (KRAS(mt)) colorectal cancers.

  9. Results confirm that CEACAM6 promoted cell proliferation mediated by cyclin D1 (show CCND1 Antibodies)/CDK4.

  10. This review highlights our current understanding of CDK signaling in both normal and malignant breast tissues, with special attention placed on recent clinical advances in inhibition of CDK4/6 in ER+ disease

Pig (Porcine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (show GJA1 Antibodies) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

Mouse (Murine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Cdk4 protein

  2. The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (show SOD2 Antibodies).

  3. a crucial role of RXRa (show RXRA Antibodies) in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS (show NRAS Antibodies)(Q61K) and altered expression of p53 (show TP53 Antibodies) and PTEN (show PTEN Antibodies)

  4. Our data indicate that Cdk2 (show CDK2 Antibodies) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Antibodies) inhibitors for cancer therapy.

  5. CDK4 is a critical downstream target of MEN1 (show MEN1 Antibodies)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (show CDK2 Antibodies) is dispensable for tumorigenesis in these neuroendocrine cell types.

  6. Cdk4 and Cdk6 (show CDK6 Antibodies) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 Antibodies) in sequestering INK4 (show CDKN2A Antibodies) proteins away from Cdk4.

  7. CDK4 seems to be expressed as multiple proteins that respond differently to different shRNAs, and have previously unrecognized functions at the S-G 2/M phases of the cell cycle via mechanisms independent of binding to CCND and RB.

  8. insulin (show INS Antibodies) activates cyclin D1 (show CCND1 Antibodies)-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 (show KAT2A Antibodies) acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression

  9. CDK4 deficiency markedly accelerated lymphoma development in the Emu-Myc (show MYC Antibodies) transgenic model of B lymphoma

  10. Cdk4- and Arf-mutant mice exhibited similar profiles, the Trp53(F/F) ::Tyr-Cre(ER)::Tyr-NRAS melanomas were strikingly different, showing relative down-regulation of melanocyte-related genes, and up-regulation of genes related to neural differentiation.

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.

  2. CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (show NRF1 Antibodies) and consequent induction of Tfam (show TFAM Antibodies) and mitochondrial ribossomal transcription.

  3. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue

  4. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos

  5. mRpL12 (show MRPL12 Antibodies) is required for CycD/Cdk4-induced cell growth

  6. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

CDK4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names and synonyms associated with CDK4

  • cyclin-dependent kinase 4 (cdk4) antibody
  • cyclin-dependent kinase 4 (CDK4) antibody
  • cyclin-dependent kinase 4 (Cdk4) antibody
  • Cyclin-dependent kinase 4 (Cdk4) antibody
  • 8-6 antibody
  • cdk antibody
  • cdk4 antibody
  • cdk4/6 antibody
  • CG5072 antibody
  • CMM3 antibody
  • Crk3 antibody
  • dCdk4 antibody
  • DmCdk4 antibody
  • Dmel\\CG5072 antibody
  • l(2)05428 antibody
  • l(2)0671 antibody
  • l(2)k06503 antibody
  • l(2)s4639 antibody
  • l(2)sh0671 antibody
  • Pk53C antibody
  • Pk?7 antibody
  • PSK-J3 antibody
  • xcdk4 antibody
  • zgc:153726 antibody

Protein level used designations for CDK4

cell division protein kinase 4 , PSK-J3 , cyclin dependent kinase 4 , p34/cdk4 , serine/threonine kinase , Cell division protein kinase 4 , CG5072-PA , CG5072-PB , CG5072-PC , Cdk4-PA , Cdk4-PB , Cdk4-PC , Cyclin-dependent kinase 4/6 , cyclin-dependent kinase 4 , protein kinase-like 53C

777730 Danio rerio
1019 Homo sapiens
100144492 Sus scrofa
12567 Mus musculus
94201 Rattus norvegicus
481131 Canis lupus familiaris
510618 Bos taurus
100009039 Oryctolagus cuniculus
100717960 Cavia porcellus
100144756 Ovis aries
36854 Drosophila melanogaster
379406 Xenopus laevis
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