You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our anti-CDK4 (CDK4) Antibodies

Full name:
anti-Cyclin-Dependent Kinase 4 Antibodies (CDK4)
On www.antibodies-online.com are 264 Cyclin-Dependent Kinase 4 (CDK4) Antibodies from 29 different suppliers available. Additionally we are shipping CDK4 Proteins (38) and CDK4 Kits (37) and many more products for this protein. A total of 352 CDK4 products are currently listed.
Synonyms:
8-6, cdk, cdk4, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726

All available anti-CDK4 Antibodies

Go to our pre-filtered search.

Top referenced anti-CDK4 Antibodies

  1. Human Monoclonal CDK4 Primary Antibody for IF, WB - ABIN393627 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN393627

  2. Human Monoclonal CDK4 Primary Antibody for IHC (f), IF - ABIN967778 : Angus, Wheeler, Ranmal, Zhang, Markey, Mathews, Knudsen: Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN967778

  3. Human Polyclonal CDK4 Primary Antibody for EIA, IHC (p) - ABIN359662 : Mori, Yang, Kawamata, Miller, Mizoguchi, Koeffler: Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors. in International journal of hematology 2003 (PubMed)
    Show all 5 references for ABIN359662

  4. Human Polyclonal CDK4 Primary Antibody for FACS, IF - ABIN391751 : Ramirez, Herbert, Vaughan, Zou, Gandia, Morales, Wright, Shay: Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. in Oncogene 2003 (PubMed)
    Show all 3 references for ABIN391751

  5. Human Monoclonal CDK4 Primary Antibody for IP, WB - ABIN967404 : Graña, Reddy: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). in Oncogene 1995 (PubMed)
    Show all 3 references for ABIN967404

  6. Dog (Canine) Monoclonal CDK4 Primary Antibody for BI, IHC (fro) - ABIN967650 : Depoortere, Van Keymeulen, Lukas, Costagliola, Bartkova, Dumont, Bartek, Roger, Dremier: A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes. in The Journal of cell biology 1998 (PubMed)
    Show all 3 references for ABIN967650

  7. Human Monoclonal CDK4 Primary Antibody for IF, WB - ABIN1106647 : Demetrick, Zhang, Beach: Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. in Cytogenetics and cell genetics 1994 (PubMed)
    Show all 2 references for ABIN1106647

  8. Human Monoclonal CDK4 Primary Antibody for IHC (f), IP - ABIN967647 : Johnson, Walker: Cyclins and cell cycle checkpoints. in Annual review of pharmacology and toxicology 1999 (PubMed)
    Show all 2 references for ABIN967647

  9. Human Polyclonal CDK4 Primary Antibody for IF (p), IHC (p) - ABIN671166 : Zhou, Liu, Cai, Liu, Jiang, Wang: Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells. in Molecular medicine reports 2015 (PubMed)
    Show all 2 references for ABIN671166

  10. Cow (Bovine) Polyclonal CDK4 Primary Antibody for WB - ABIN2792086 : Elkahloun, Krizman, Wang, Hofmann, Roe, Meltzer: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. in Genomics 1997 (PubMed)

More Antibodies against CDK4 Interaction Partners

Zebrafish Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.

Human Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. amplification of HMGA2 was associated with the atypical lipomatous tumor/well-differentiated liposarcoma histological type and a good prognosis, whereas CDK4 and JUN (show JUN Antibodies) amplifications were associated with dedifferentiated liposarcoma histology

  2. CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma

  3. Observations disclose the presence of CDK4 protein in human erythrocytes and its involvement in suicidal erythrocyte death.

  4. Ewing sarcoma cells require CDK4 and cyclin D1 (show CCND1 Antibodies) for survival and anchorage-independent growth.

  5. Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 (show BCL2 Antibodies) and CDK-4/Cyclin D1 (show CCND1 Antibodies).

  6. Data show that the p16/CDKN2A (show CDKN2A Antibodies)-cyclin-dependent kinase 4 (CDK4)-RB1 (show RB1 Antibodies) protein pathway is frequently disrupted in fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP).

  7. The results of clinical trials with oral CDK4/6 inhibitors to date have offered promising glimpses of significant activity in hormone-sensitive breast cancer.

  8. shRNA-mediated knockdown or chemical inhibition of CDK4 prevented the increase in cell size associated with the senescent phenotype by allowing the cells to arrest in G1 rather than G2/M.

  9. Prevalence of Germline BAP1 (show RNF2 Antibodies), CDKN2A (show CDKN2A Antibodies), and CDK4 Mutations in an Australian Population-Based Sample of Cutaneous Melanoma Cases

  10. Diclofenac and curcumin overcome these carcinogenic effects by downregulating telomerase activity, diminishing the expression of TERT (show TERT Antibodies), CDK4, CDK2 (show CDK2 Antibodies), cyclin D1 (show CCND1 Antibodies), and cyclin E (show CCNE1 Antibodies).

Pig (Porcine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (show GJA1 Antibodies) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

Mouse (Murine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Cdk4 protein

  2. The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (show SOD2 Antibodies).

  3. a crucial role of RXRa (show RXRA Antibodies) in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS (show NRAS Antibodies)(Q61K) and altered expression of p53 (show TP53 Antibodies) and PTEN (show PTEN Antibodies)

  4. Our data indicate that Cdk2 (show CDK2 Antibodies) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Antibodies) inhibitors for cancer therapy.

  5. CDK4 is a critical downstream target of MEN1 (show MEN1 Antibodies)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (show CDK2 Antibodies) is dispensable for tumorigenesis in these neuroendocrine cell types.

  6. Cdk4 and Cdk6 (show CDK6 Antibodies) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 Antibodies) in sequestering INK4 (show CDKN2A Antibodies) proteins away from Cdk4.

  7. CDK4 seems to be expressed as multiple proteins that respond differently to different shRNAs, and have previously unrecognized functions at the S-G 2/M phases of the cell cycle via mechanisms independent of binding to CCND and RB.

  8. insulin (show INS Antibodies) activates cyclin D1 (show CCND1 Antibodies)-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 (show KAT2A Antibodies) acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression

  9. CDK4 deficiency markedly accelerated lymphoma development in the Emu-Myc (show MYC Antibodies) transgenic model of B lymphoma

  10. Cdk4- and Arf-mutant mice exhibited similar profiles, the Trp53(F/F) ::Tyr-Cre(ER)::Tyr-NRAS melanomas were strikingly different, showing relative down-regulation of melanocyte-related genes, and up-regulation of genes related to neural differentiation.

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (show NRF1 Antibodies) and consequent induction of Tfam (show TFAM Antibodies) and mitochondrial ribossomal transcription.

  2. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue

  3. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos

  4. mRpL12 (show MRPL12 Antibodies) is required for CycD/Cdk4-induced cell growth

  5. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

CDK4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names and synonyms associated with CDK4

  • cyclin-dependent kinase 4 (cdk4) antibody
  • cyclin-dependent kinase 4 (CDK4) antibody
  • cyclin-dependent kinase 4 (Cdk4) antibody
  • Cyclin-dependent kinase 4 (Cdk4) antibody
  • 8-6 antibody
  • cdk antibody
  • cdk4 antibody
  • cdk4/6 antibody
  • CG5072 antibody
  • CMM3 antibody
  • Crk3 antibody
  • dCdk4 antibody
  • DmCdk4 antibody
  • Dmel\\CG5072 antibody
  • l(2)05428 antibody
  • l(2)0671 antibody
  • l(2)k06503 antibody
  • l(2)s4639 antibody
  • l(2)sh0671 antibody
  • Pk53C antibody
  • Pk?7 antibody
  • PSK-J3 antibody
  • xcdk4 antibody
  • zgc:153726 antibody

Protein level used designations for CDK4

cell division protein kinase 4 , PSK-J3 , cyclin dependent kinase 4 , p34/cdk4 , serine/threonine kinase , Cell division protein kinase 4 , CG5072-PA , CG5072-PB , CG5072-PC , Cdk4-PA , Cdk4-PB , Cdk4-PC , Cyclin-dependent kinase 4/6 , cyclin-dependent kinase 4 , protein kinase-like 53C

GENE ID SPECIES
777730 Danio rerio
1019 Homo sapiens
100144492 Sus scrofa
12567 Mus musculus
94201 Rattus norvegicus
481131 Canis lupus familiaris
510618 Bos taurus
100009039 Oryctolagus cuniculus
100717960 Cavia porcellus
100144756 Ovis aries
36854 Drosophila melanogaster
379406 Xenopus laevis
Selected quality suppliers for anti-CDK4 (CDK4) Antibodies
Did you look for something else?