Browse our anti-CDK4 (CDK4) Antibodies

On www.antibodies-online.com are 320 Cyclin-Dependent Kinase 4 (CDK4) Antibodies from 34 different suppliers available. Additionally we are shipping CDK4 Proteins (41) and CDK4 Kits (35) and many more products for this protein. A total of 409 CDK4 products are currently listed.
Synonyms:
8-6, cdk, cdk4, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726
list all antibodies Gene Name GeneID UniProt
CDK4 1019 P11802
CDK4 12567 P30285
CDK4 94201 P35426

Most Popular Reactivities for anti-CDK4 (CDK4) Antibodies

anti-Human CDK4 Antibodies:

anti-Mouse (Murine) CDK4 Antibodies:

anti-Rat (Rattus) CDK4 Antibodies:

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More Antibodies against CDK4 Interaction Partners

Zebrafish Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.

Human Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (show E2F1 Antibodies) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 inhibitors in breast cancer for the development of more effective combination therapies.

  2. p16 (show CDKN2A Antibodies) in combination with MDM2 (show MDM2 Antibodies) and CDK4 immunohistochemistry may help in the differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

  3. conclude that p16 (show CDKN2A Antibodies) is highly sensitive for retroperitoneal DDL. However, the lack of specificity limits the diagnostic utility compared with the more established markers MDM2 (show MDM2 Antibodies) and CDK4

  4. CDK4 overexpression is associated with cancer.

  5. High CDK4 expression is associated with Melanoma.

  6. Staining for MDM2 (show MDM2 Antibodies) and CDK4 was noted in 25/56 and 23/56 atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), respectively, giving a sensitivity of 45% and 41% and a specificity of 98% and 92%. Staining was noted exclusively in the nuclei of atypical cells and not in the nuclei of adipocytes. Staining for MDM2 (show MDM2 Antibodies) and CDK4 occurred in 2/125 and 10/117 benign lipomatous lesions, respectively.

  7. Data suggest that CDK4 (cyclin-dependent kinase 4) is degraded by anaphase-promoting complex/cyclosome (APC (show APC Antibodies)/C) during metaphase-anaphase transition while its main regulator, cyclin D1 (show CCND1 Antibodies), remains intact but is sequestered in cytoplasm; CDK4 protein reaccumulates in the following G1 phase and shuttles between nucleus and cytoplasm to facilitate nuclear import of cyclin D1 (show CCND1 Antibodies); without CDK4, cyclin D1 (show CCND1 Antibodies) cannot enter nucleus.

  8. Cdk4 inhibition leads to directing human mesenchymal stem cells to a multipotent neurogenic fate by inactivating Smads-STAT3 (show STAT3 Antibodies) signaling.

  9. Reduced SIRT2 (show SIRT2 Antibodies) expression during tumorigenesis failed to repress cyclindependent kinase 4 expression, which eventually led to accelerated cell proliferation.

  10. older patients with head and neck squamous cell carcinoma and lung cancer have raised serums CDK4 levels, which has the potential to emerge as a biomarker in clinical practice

Pig (Porcine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (show GJA1 Antibodies) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

Mouse (Murine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.

  2. Cdk4 protein

  3. The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (show SOD2 Antibodies).

  4. a crucial role of RXRa (show RXRA Antibodies) in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS (show NRAS Antibodies)(Q61K) and altered expression of p53 (show TP53 Antibodies) and PTEN (show PTEN Antibodies)

  5. Our data indicate that Cdk2 (show CDK2 Antibodies) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Antibodies) inhibitors for cancer therapy.

  6. CDK4 is a critical downstream target of MEN1 (show MEN1 Antibodies)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (show CDK2 Antibodies) is dispensable for tumorigenesis in these neuroendocrine cell types.

  7. Cdk4 and Cdk6 (show CDK6 Antibodies) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 Antibodies) in sequestering INK4 (show CDKN2A Antibodies) proteins away from Cdk4.

  8. CDK4 seems to be expressed as multiple proteins that respond differently to different shRNAs, and have previously unrecognized functions at the S-G 2/M phases of the cell cycle via mechanisms independent of binding to CCND and RB.

  9. insulin (show INS Antibodies) activates cyclin D1 (show CCND1 Antibodies)-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 (show KAT2A Antibodies) acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression

  10. CDK4 deficiency markedly accelerated lymphoma development in the Emu-Myc (show MYC Antibodies) transgenic model of B lymphoma

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.

  2. CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (show NRF1 Antibodies) and consequent induction of Tfam (show TFAM Antibodies) and mitochondrial ribossomal transcription.

  3. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue

  4. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos

  5. mRpL12 (show MRPL12 Antibodies) is required for CycD/Cdk4-induced cell growth

  6. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

CDK4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names and synonyms associated with CDK4

  • cyclin-dependent kinase 4 (cdk4) antibody
  • cyclin-dependent kinase 4 (CDK4) antibody
  • cyclin-dependent kinase 4 (Cdk4) antibody
  • Cyclin-dependent kinase 4 (Cdk4) antibody
  • 8-6 antibody
  • cdk antibody
  • cdk4 antibody
  • cdk4/6 antibody
  • CG5072 antibody
  • CMM3 antibody
  • Crk3 antibody
  • dCdk4 antibody
  • DmCdk4 antibody
  • Dmel\\CG5072 antibody
  • l(2)05428 antibody
  • l(2)0671 antibody
  • l(2)k06503 antibody
  • l(2)s4639 antibody
  • l(2)sh0671 antibody
  • Pk53C antibody
  • Pk?7 antibody
  • PSK-J3 antibody
  • xcdk4 antibody
  • zgc:153726 antibody

Protein level used designations for CDK4

cell division protein kinase 4 , PSK-J3 , cyclin dependent kinase 4 , p34/cdk4 , serine/threonine kinase , Cell division protein kinase 4 , CG5072-PA , CG5072-PB , CG5072-PC , Cdk4-PA , Cdk4-PB , Cdk4-PC , Cyclin-dependent kinase 4/6 , cyclin-dependent kinase 4 , protein kinase-like 53C

GENE ID SPECIES
777730 Danio rerio
1019 Homo sapiens
100144492 Sus scrofa
12567 Mus musculus
94201 Rattus norvegicus
481131 Canis lupus familiaris
510618 Bos taurus
100009039 Oryctolagus cuniculus
100717960 Cavia porcellus
100144756 Ovis aries
36854 Drosophila melanogaster
379406 Xenopus laevis
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