Browse our anti-SMAD4 (SMAD4) Antibodies

Full name:
anti-SMAD Family Member 4 Antibodies (SMAD4)
On are 172 SMAD Family Member 4 (SMAD4) Antibodies from 27 different suppliers available. Additionally we are shipping SMAD4 Kits (39) and SMAD4 Proteins (22) and many more products for this protein. A total of 254 SMAD4 products are currently listed.
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha
list all antibodies Gene Name GeneID UniProt
SMAD4 4089 Q13485
SMAD4 17128 P97471
SMAD4 50554 O70437

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Most Popular Reactivities for anti-SMAD4 (SMAD4) Antibodies

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anti-Human SMAD4 Antibodies:

anti-Mouse (Murine) SMAD4 Antibodies:

anti-Rat (Rattus) SMAD4 Antibodies:

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Top referenced anti-SMAD4 Antibodies

  1. Human Polyclonal SMAD4 Primary Antibody for EIA, IHC (p) - ABIN358227 : Sekiya, Oda, Matsuura, Akiyama: Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 5 references for 358227

  2. Human Polyclonal SMAD4 Primary Antibody for IF, IHC (p) - ABIN272224 : Izumi, Nakamura, Tokumo, Mano: A minute pancreatic ductal adenocarcinoma with lipomatous pseudohypertrophy of the pancreas. in JOP : Journal of the pancreas 2011 (PubMed)
    Show all 5 references for 272224

  3. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN401410 : Karlsson, Blank, Moody, Ehinger, Singbrant, Deng, Karlsson: Smad4 is critical for self-renewal of hematopoietic stem cells. in The Journal of experimental medicine 2007 (PubMed)
    Show all 5 references for 401410

  4. Human Polyclonal SMAD4 Primary Antibody for ELISA, WB - ABIN1533870 : Hahn, Schutte, Hoque, Moskaluk, da Costa, Rozenblum, Weinstein, Fischer, Yeo, Hruban, Kern: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. in Science (New York, N.Y.) 1996 (PubMed)
    Show all 2 references for 1533870

  5. Human Polyclonal SMAD4 Primary Antibody for DB, IF - ABIN389658 : Maru, Wu, Canada, Houlihan, Hamilton, Rashid: Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas. in Oncogene 2004 (PubMed)
    Show all 2 references for 389658

  6. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for WB - ABIN2779413 : Kantola, Keski-Oja, Koli: Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements. in Gene 2005 (PubMed)

  7. Mouse (Murine) Polyclonal SMAD4 Primary Antibody for ELISA, WB - ABIN184619 : Kim, Fan, Papadimitrakopoulou, Clayman, Hittelman, Hong, Lotan, Mao: DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. in Cancer research 1996 (PubMed)

  8. Human Monoclonal SMAD4 Primary Antibody for FACS - ABIN4895797 : Geng, Chen, Yuan, Peng, Maitra, Diao, Chen, Zhang, Hu, Qi, Pierce, Ling, Xiong, Li: The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis. in Nature communications 2016 (PubMed)

  9. Human Polyclonal SMAD4 Primary Antibody for IF, WB - ABIN392165 : Lessard, Rivas, Alves-Wagner, Hirshman, Gallagher, Constantin-Teodosiu, Atkins, Greenhaff, Qi, Gustafsson, Fielding, Timmons, Britton, Koch, Goodyear: Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. in Diabetes 2013 (PubMed)

  10. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for IHC, WB - ABIN2780673 : Aitchison, Veerakumarasivam, Vias, Kumar, Hamdy, Neal, Mills: Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. in The Prostate 2008 (PubMed)

More Antibodies against SMAD4 Interaction Partners

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG (show ENG Antibodies), two in BMPR1A (show BMPR1A Antibodies), one in PTEN (show PTEN Antibodies), and one in SMAD4. Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.

  2. Expression levels of Smad4 and miR (show MLXIP Antibodies)-34a in colorectal cancer patients had a significant inverse correlation and overexpressing miR (show MLXIP Antibodies)-34a inhibited macroautophagy activation by directly targeting Smad4 through the TGF-beta (show TGFB1 Antibodies)/Smad4 pathway.

  3. MAD4 (show MXD4 Antibodies) has been found to regulate epithelial-mesenchymal transition, co-immunopurification, and glutathione S-transferase (show GSTa2 Antibodies) pull-down analysis demonstrated that USP17 interacted with SMAD4. Furthermore, USP17 stabilized SMAD4 through its deubiquitinase activity. In conclusion, this study shows that USP17 enhances osteosarcoma cell proliferation and invasion through stabilizing SMAD4.

  4. Upon SMAD4 deletion, we detected high expression levels of FYN (show FYN Antibodies) in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype

  5. our data suggest that miR (show MLXIP Antibodies)-1285-5p functions as a tumor promoter in the development of non-small-cell lung carcinoma by targeting Smad4 and CDH1 (show CDH1 Antibodies), indicating a novel therapeutic strategy for non-small-cell lung carcinoma patients.

  6. SENP1 (show SENP1 Antibodies) deSUMOylated SMAD4 to promote EMT (show ITK Antibodies) via up-regulating E-cadherin (show CDH1 Antibodies) in prostate cancer cells. Therefore, SENP1 (show SENP1 Antibodies) is a potential target for treatment of advanced prostate cancer.

  7. TGF-beta (show TGFB1 Antibodies)-treated fibroblasts contained SMAD (show SMAD1 Antibodies) complexes that activated a SMAD (show SMAD1 Antibodies) target gene in addition to those repressing PPARG (show PPARG Antibodies) transcription, the first finding of such dual activity within the same cell. These findings describe in detail novel mechanisms by which TGF-beta (show TGFB1 Antibodies) represses PPARG (show PPARG Antibodies) transcription, thereby facilitating its own pro-fibrotic activity

  8. The 1244_1247delACAG mutation of SMAD4 is the cause of juvenile polyposis syndrome and the likely cause of Menetrier's disease (MD) in a large family initially diagnosed with MD.

  9. The nuclear importin (show KPNA4 Antibodies) IPO5 (show IPO5 Antibodies) was identified as a novel interacting protein of SMAD1 (show GARS Antibodies). Overexpression of IPO5 (show IPO5 Antibodies) in various cell lines specifically increases nuclear localization of BMP receptor (show BMPR1A Antibodies)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (show IPO5 Antibodies) and BMP but not TGF-beta (show TGFB1 Antibodies) R-SMADs.

  10. The phenotype of juvenile polyposis syndrome with hereditary hemorrhagic telangiectasia caused by the SMAD4 mutations has been described.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. deletion of Smad4 in OBs (show LEP Antibodies) differentially modulates HSC (show FUT1 Antibodies) fate in a stage-dependent manner

  2. Data suggest that ovarian Bmp4 (show BMP4 Antibodies) levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 (show BMP4 Antibodies) expression via activation of androgen receptors; Smad4 signaling rather than p38 MAPK (show MAPK14 Antibodies) pathway regulates androgen and estrogen formation.

  3. The authors demonstrated that ubiquitin-specific protease (USP) 4 (show USP4 Antibodies) strongly induces activin (show Actbeta Antibodies)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4.

  4. SMAD4 and STRA8 (show STRA8 Antibodies) are essential factors that regulate the female fate of germ cells.

  5. Smad4 is necessary for the activation of the mineralization-related genes, it is dispensable for BMP2 (show BMP2 Antibodies) to induce the protein anabolism signature, which instead critically depends on the transcription factor Atf4 (show ATF4 Antibodies).

  6. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (show VEGFC Antibodies) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  7. MZF1 (show ZSCAN1 Antibodies) has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1 (show ZSCAN1 Antibodies)-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.

  8. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

  9. Smad4 deficiency led to aberrant transcriptional programs in antigen-specific CD8 (show CD8A Antibodies)(+) T cells. Findings demonstrated an essential role of Smad4 in the control of effector and memory CD8 (show CD8A Antibodies)(+) T-cell responses to infection.

  10. Data show that transforming growth factor beta (TGFbeta (show TGFB1 Antibodies))-induced changes in Gata2 transcription factor (show GATA2 Antibodies) and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C Antibodies)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Antibodies) signaling via Smad4 protein.

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  2. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 Antibodies).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST Antibodies) are SMAD4 dependent.

  2. ALK5 (show TGFBR1 Antibodies) and Smad4 have roles in TGF-beta1 (show TGFB1 Antibodies)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (show TGFB1 Antibodies) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Antigen Profile

Antigen Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4) antibody
  • Smad4 protein (smad4) antibody
  • mothers against decapentaplegic homolog 4 (LOC100342294) antibody
  • SMAD family member 4 (Smad4) antibody
  • SMAD family member 4, gene 1 (smad4.1) antibody
  • AW743858 antibody
  • D18Wsu70e antibody
  • dpc4 antibody
  • jip antibody
  • madh4 antibody
  • MYHRS antibody
  • smad4 antibody
  • Xsmad4 antibody
  • xsmad4a antibody
  • XSmad4alpha antibody

Protein level used designations for SMAD4

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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