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Browse our anti-SMAD4 (SMAD4) Antibodies

Full name:
anti-SMAD Family Member 4 Antibodies (SMAD4)
On www.antibodies-online.com are 162 SMAD Family Member 4 (SMAD4) Antibodies from 25 different suppliers available. Additionally we are shipping SMAD4 Kits (43) and SMAD4 Proteins (22) and many more products for this protein. A total of 249 SMAD4 products are currently listed.
Synonyms:
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha
list all antibodies Gene Name GeneID UniProt
SMAD4 4089 Q13485
SMAD4 17128 P97471
SMAD4 50554 O70437

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anti-Human SMAD4 Antibodies:

anti-Mouse (Murine) SMAD4 Antibodies:

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Top referenced anti-SMAD4 Antibodies

  1. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN401410 : Karlsson, Blank, Moody, Ehinger, Singbrant, Deng, Karlsson: Smad4 is critical for self-renewal of hematopoietic stem cells. in The Journal of experimental medicine 2007 (PubMed)
    Show all 5 references for ABIN401410

  2. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN360050 : Warrier, Lo, Monbouquette, Garcia-Garibay: Photocatalytic reduction of aromatic azides to amines using CdS and CdSe nanoparticles. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2004 (PubMed)
    Show all 5 references for ABIN360050

  3. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN453833 : Sekiya, Oda, Matsuura, Akiyama: Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 5 references for ABIN453833

  4. Human Polyclonal SMAD4 Primary Antibody for EIA, IHC (p) - ABIN358227 : Horvath, Henshall, Kench, Turner, Golovsky, Brenner, ONeill, Kooner, Stricker, Grygiel, Sutherland: Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. in The Prostate 2004 (PubMed)
    Show all 5 references for ABIN358227

  5. Human Polyclonal SMAD4 Primary Antibody for DB, IF - ABIN389658 : Maru, Wu, Canada, Houlihan, Hamilton, Rashid: Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas. in Oncogene 2004 (PubMed)
    Show all 2 references for ABIN389658

  6. Human Polyclonal SMAD4 Primary Antibody for ELISA, WB - ABIN1533870 : Hahn, Schutte, Hoque, Moskaluk, da Costa, Rozenblum, Weinstein, Fischer, Yeo, Hruban, Kern: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. in Science (New York, N.Y.) 1996 (PubMed)
    Show all 2 references for ABIN1533870

  7. Human Polyclonal SMAD4 Primary Antibody for IF, WB - ABIN392165 : Lessard, Rivas, Alves-Wagner, Hirshman, Gallagher, Constantin-Teodosiu, Atkins, Greenhaff, Qi, Gustafsson, Fielding, Timmons, Britton, Koch, Goodyear: Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. in Diabetes 2013 (PubMed)

  8. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN782879 : Kim, Fan, Papadimitrakopoulou, Clayman, Hittelman, Hong, Lotan, Mao: DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. in Cancer research 1996 (PubMed)

  9. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for WB - ABIN2779413 : Kantola, Keski-Oja, Koli: Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements. in Gene 2005 (PubMed)

  10. Human Polyclonal SMAD4 Primary Antibody for WB - ABIN2780673 : Aitchison, Veerakumarasivam, Vias, Kumar, Hamdy, Neal, Mills: Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. in The Prostate 2008 (PubMed)

More Antibodies against SMAD4 Interaction Partners

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. we discovered a novel mechanism mediated by Smad4 to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/CDC2 (show CDK1 Antibodies)/survivin (show BIRC5 Antibodies) cascade.

  2. Study shows the upregulation of miR (show MLXIP Antibodies)-130a and inactivation of Smad4 in gemcitabine resistant hepatocellular carcinoma cells, (HCC (show FAM126A Antibodies)) and describes a potential mechanism for dysregulation of Smad4 by miR (show MLXIP Antibodies)-130a-3p in HCC (show FAM126A Antibodies).

  3. Loss of SMAD4 was significantly associated with CCL15 (show CCL15 Antibodies) expression.

  4. germline SMAD4 gene mutation is associated with gastric polyposis.

  5. The reverse correlation of Jab1 (show COPS5 Antibodies) and Smad4 in PANC-1 cells may be involved in the Pathogenesis of prostate cancer. Jab1 (show COPS5 Antibodies) can cause degradation of Smad4 via TGF-beta (show TGFB1 Antibodies) signal pathway.

  6. data suggest that TGF-beta1 (show TGFB1 Antibodies) enhances IGFBP7 (show IGFBP7 Antibodies) via Smad2 (show SMAD2 Antibodies)/4 pathways, and that IGFBP7 (show IGFBP7 Antibodies) might be involved in the TGF-beta1 (show TGFB1 Antibodies)-induced tubular injury in DN.

  7. Studies establish Smad4 as a lung tumor suppressor and suggest that the defective DNA repair phenotype of Smad4-deficient tumors can be exploited by specific therapeutic strategies.

  8. Microarray analysis of gene expression at 8, 24, and 48 hours after SMAD4 expression characterized the regulatory impact of SMAD4 expression in a SMAD4-null pancreatic ductal adenocarcinoma cell line and identified novel targets of TGF-beta (show TGFB1 Antibodies) signaling.

  9. Transcription factor SMAD4 (a part of the TGF-beta (show TGFB1 Antibodies) signaling pathway) activates Fn14 (show TNFRSF12A Antibodies) expression. Then, activated Fn14 (show TNFRSF12A Antibodies) expression increases extracellular matrix synthesis and fibroblast activation.

  10. In operated pancreatic adenocarcinoma, incidence of mutations was: SMAD4 = 20%.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Smad4 deficiency led to aberrant transcriptional programs in antigen-specific CD8 (show CD8A Antibodies)(+) T cells. Findings demonstrated an essential role of Smad4 in the control of effector and memory CD8 (show CD8A Antibodies)(+) T-cell responses to infection.

  2. Data show that transforming growth factor beta (TGFbeta (show TGFB1 Antibodies))-induced changes in Gata2 transcription factor (show GATA2 Antibodies) and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C Antibodies)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Antibodies) signaling via Smad4 protein.

  3. Smad4 knockdown blocks the effects of miR (show MLXIP Antibodies)-144-3p inhibitor. MiR (show MLXIP Antibodies)-144-3p negatively regulates osteogenic differentiation and proliferation of C3H10T1/2 cells by targeting Smad4.

  4. Studies establish Smad4 as a lung tumor suppressor and suggest that the defective DNA repair phenotype of Smad4-deficient tumors can be exploited by specific therapeutic strategies.

  5. Smad4-dependent TGF-beta (show TGFB1 Antibodies) signaling in smooth muscle cells protects against aortic aneurysm formation and dissection.

  6. the interplay between TGFalpha and TGF-beta (show TGFB1 Antibodies) signaling in pancreatic tumorigenesis

  7. The findings suggest that Smad4 is essential for initiating the ureteral smooth muscle cell differentiation program during ureter development.

  8. During high-fat diet, fed and fasting blood glucose levels, glucose stimulated insulin (show INS Antibodies) secretion, disposition index and glucose tolerance were significantly improved in beta-Smad4KO mice as compared with wild-type mice.

  9. This study showed that Smad4 in the oocyte is not required for oocyte or follicle development, ovulation, fertilization, preimplantation development (show MTA2 Antibodies), or implantation.

  10. The results of this study suggest that Smad4 knockdown is one of the crucial therapeutic options for the prevention of renal fibrosis in vivo

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  2. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 Antibodies).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST Antibodies) are SMAD4 dependent.

  2. ALK5 (show TGFBR1 Antibodies) and Smad4 have roles in TGF-beta1 (show TGFB1 Antibodies)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (show TGFB1 Antibodies) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Antigen Profile

Antigen Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4) antibody
  • Smad4 protein (smad4) antibody
  • mothers against decapentaplegic homolog 4 (LOC100342294) antibody
  • SMAD family member 4 (Smad4) antibody
  • SMAD family member 4, gene 1 (smad4.1) antibody
  • AW743858 antibody
  • D18Wsu70e antibody
  • dpc4 antibody
  • jip antibody
  • madh4 antibody
  • MYHRS antibody
  • smad4 antibody
  • Xsmad4 antibody
  • xsmad4a antibody
  • XSmad4alpha antibody

Protein level used designations for SMAD4

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

GENE ID SPECIES
701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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