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Browse our anti-SMAD4 (SMAD4) Antibodies

Full name:
anti-SMAD Family Member 4 Antibodies (SMAD4)
On www.antibodies-online.com are 174 SMAD Family Member 4 (SMAD4) Antibodies from 27 different suppliers available. Additionally we are shipping SMAD4 Kits (37) and SMAD4 Proteins (23) and many more products for this protein. A total of 255 SMAD4 products are currently listed.
Synonyms:
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha
list all antibodies Gene Name GeneID UniProt
SMAD4 4089 Q13485
SMAD4 17128 P97471
SMAD4 50554 O70437

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Most Popular Reactivities for anti-SMAD4 (SMAD4) Antibodies

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anti-Human SMAD4 Antibodies:

anti-Mouse (Murine) SMAD4 Antibodies:

anti-Rat (Rattus) SMAD4 Antibodies:

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Top referenced anti-SMAD4 Antibodies

  1. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN453833 : Warrier, Lo, Monbouquette, Garcia-Garibay: Photocatalytic reduction of aromatic azides to amines using CdS and CdSe nanoparticles. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2004 (PubMed)
    Show all 5 references for ABIN453833

  2. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN401410 : Karlsson, Blank, Moody, Ehinger, Singbrant, Deng, Karlsson: Smad4 is critical for self-renewal of hematopoietic stem cells. in The Journal of experimental medicine 2007 (PubMed)
    Show all 5 references for ABIN401410

  3. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN4620442 : Sekiya, Oda, Matsuura, Akiyama: Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 5 references for ABIN4620442

  4. Human Polyclonal SMAD4 Primary Antibody for EIA, IHC (p) - ABIN358227 : Horvath, Henshall, Kench, Turner, Golovsky, Brenner, ONeill, Kooner, Stricker, Grygiel, Sutherland: Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. in The Prostate 2004 (PubMed)
    Show all 5 references for ABIN358227

  5. Human Polyclonal SMAD4 Primary Antibody for ELISA, WB - ABIN1533870 : Hahn, Schutte, Hoque, Moskaluk, da Costa, Rozenblum, Weinstein, Fischer, Yeo, Hruban, Kern: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. in Science (New York, N.Y.) 1996 (PubMed)
    Show all 2 references for ABIN1533870

  6. Human Polyclonal SMAD4 Primary Antibody for DB, IF - ABIN389658 : Maru, Wu, Canada, Houlihan, Hamilton, Rashid: Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas. in Oncogene 2004 (PubMed)
    Show all 2 references for ABIN389658

  7. Human Polyclonal SMAD4 Primary Antibody for IF, WB - ABIN392165 : Lessard, Rivas, Alves-Wagner, Hirshman, Gallagher, Constantin-Teodosiu, Atkins, Greenhaff, Qi, Gustafsson, Fielding, Timmons, Britton, Koch, Goodyear: Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. in Diabetes 2013 (PubMed)

  8. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for WB - ABIN2779413 : Kantola, Keski-Oja, Koli: Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements. in Gene 2005 (PubMed)

  9. Human Polyclonal SMAD4 Primary Antibody for WB - ABIN2780673 : Aitchison, Veerakumarasivam, Vias, Kumar, Hamdy, Neal, Mills: Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. in The Prostate 2008 (PubMed)

  10. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN374104 : Kim, Fan, Papadimitrakopoulou, Clayman, Hittelman, Hong, Lotan, Mao: DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. in Cancer research 1996 (PubMed)

More Antibodies against SMAD4 Interaction Partners

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. Loss of heterozygosity of TP53 (show TP53 Antibodies), P16 (show CDKN2A Antibodies), SMAD4 and APC (show APC Antibodies) genes was observed in esophageal adenocarcinoma.

  2. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (show VEGFC Antibodies) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  3. In this study, we confirmed that overexpression of miR205 suppressed the expression of Smad4, in turn, weakened the TGF-b/Smad (show SMAD1 Antibodies) signaling pathway and inhibited TGF-b/Smad4-induced EMT (show ITK Antibodies), invasion and migration ultimately.

  4. A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 Antibodies) and both zeta-chain-associated protein kinase (show CDK7 Antibodies) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (show SMAD2 Antibodies)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS Antibodies)/8 and lower SMAD-4 expression in chronic lymphocytic leukemia cells

  5. In colorectal cancer, it was found that the level of SMAD-4 gene expression was not associated with the analyzed parameters of clinical staging.

  6. Treatment with brefelamide induced Smad4 expression, and knockdown of Smad4 by RNA interference partially diminished the inhibitory effect of brefelamide on OPN (show SPP1 Antibodies). These results indicate that brefelamide inhibited OPNmediated cell invasion through restoration of the OPN (show SPP1 Antibodies) repression by TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling

  7. The results of the present study suggested that Rac1 enhanced the expression of Smad3/4 in activated hepatic stellate cells; however, this increase may be suppressed by SAM-induced methylation of Rac1 promoters.

  8. Data indicate the TGF-beta (show TGFB1 Antibodies) pathway regulates the epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) of gastric cancer cells by increasing the levels of microRNA miRNA-181b to target Timp3 (show TIMP3 Antibodies) via the Smad2 (show SMAD2 Antibodies)/3/4-dependent pathway.

  9. Silencing of Smad4, but not Smad2 (show SMAD2 Antibodies) or Smad3 (show SMAD3 Antibodies), significantly inhibited the TGF-B1-induced miR (show MLXIP Antibodies)-574-3p upregulation in gastric tumor cells.

  10. AhR (show AHR Antibodies) affects the transforming growth factor-beta signaling pathway by inducing Smad4 degradation by the proteasome and suppressing tumor metastasis via epithelial to mesenchymal transition reduction in lung cancer cells.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (show VEGFC Antibodies) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  2. MZF1 (show ZSCAN1 Antibodies) has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1 (show ZSCAN1 Antibodies)-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.

  3. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

  4. Smad4 deficiency led to aberrant transcriptional programs in antigen-specific CD8 (show CD8A Antibodies)(+) T cells. Findings demonstrated an essential role of Smad4 in the control of effector and memory CD8 (show CD8A Antibodies)(+) T-cell responses to infection.

  5. Data show that transforming growth factor beta (TGFbeta (show TGFB1 Antibodies))-induced changes in Gata2 transcription factor (show GATA2 Antibodies) and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C Antibodies)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Antibodies) signaling via Smad4 protein.

  6. Smad4 knockdown blocks the effects of miR (show MLXIP Antibodies)-144-3p inhibitor. MiR (show MLXIP Antibodies)-144-3p negatively regulates osteogenic differentiation and proliferation of C3H10T1/2 cells by targeting Smad4.

  7. Studies establish Smad4 as a lung tumor suppressor and suggest that the defective DNA repair phenotype of Smad4-deficient tumors can be exploited by specific therapeutic strategies.

  8. Smad4-dependent TGF-beta (show TGFB1 Antibodies) signaling in smooth muscle cells protects against aortic aneurysm formation and dissection.

  9. the interplay between TGFalpha and TGF-beta (show TGFB1 Antibodies) signaling in pancreatic tumorigenesis

  10. The findings suggest that Smad4 is essential for initiating the ureteral smooth muscle cell differentiation program during ureter development.

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  2. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 Antibodies).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST Antibodies) are SMAD4 dependent.

  2. ALK5 (show TGFBR1 Antibodies) and Smad4 have roles in TGF-beta1 (show TGFB1 Antibodies)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (show TGFB1 Antibodies) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Antigen Profile

Antigen Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4) antibody
  • Smad4 protein (smad4) antibody
  • mothers against decapentaplegic homolog 4 (LOC100342294) antibody
  • SMAD family member 4 (Smad4) antibody
  • SMAD family member 4, gene 1 (smad4.1) antibody
  • AW743858 antibody
  • D18Wsu70e antibody
  • dpc4 antibody
  • jip antibody
  • madh4 antibody
  • MYHRS antibody
  • smad4 antibody
  • Xsmad4 antibody
  • xsmad4a antibody
  • XSmad4alpha antibody

Protein level used designations for SMAD4

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

GENE ID SPECIES
701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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