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Human IL17F Protein expressed in Escherichia coli (E. coli) - ABIN2667479
Hizawa, Kawaguchi, Huang, Nishimura: Role of interleukin-17F in chronic inflammatory and allergic lung disease. in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006
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Loss of IL-24 (show IL24 Proteins) expression is associated with breast cancer.
our results indicate that Th17 cells contribute to the airway vascular remodeling in asthma by mediating EPC (show TCF21 Proteins) chemotaxis, as well as PMVEC tube formation, via IL-17A (show IL17A Proteins) rather than IL-17F.
Data indicate that IL-17A (show IL17A Proteins) repressed IL-17F secretion in vitro and in vivo.
A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB (show NFKB1 Proteins) was triggered by TNFR1 (show TNFRSF1A Proteins)-dependent upregulation of interleukin-24 (show IL24 Proteins) & activation of STAT3 (show STAT3 Proteins) signaling in keratinocytes.
The concentrations in plasma of IL-17A (show IL17A Proteins), IL-17F, and the IL-17AF heterodimer all were increased greatly in mice after endotoxemia.
IL-24 (show IL24 Proteins) suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS (show ROS1 Proteins)) production through the regulation of mitochondrial ROS (show ROS1 Proteins) production and expression of antioxidant enzymes
IL-17A (show IL17A Proteins) and IL-17F secreted by CD4 (show CD4 Proteins)+Th17 cells specific to lung self-antigens are critical mediators of autoimmunity leading to the pathogenesis of obliterative airway disease.
The Th17 subset of T-lymphocytes produces IL-17F to stimulate bone healing.
IL-17F is not required for development of T helper cell (Th)2-type allergic airway inflammation.
These findings identify a novel biological function for IL-17A (show IL17A Proteins)/F as an indirect angiogenic agent.
IL-17F was correlated with increased autoantibody levels and disease activity in primary Sjogren's syndrome and is more clinically relevant than IL-17A (show IL17A Proteins).
No relationship between IL17F rs763780 and rs9463772 polymorphisms and Henoch-Schonlein purpura susceptibility.
Single nucleotide polymorphisms in IL-17F A7488G but not IL-17A (show IL17A Proteins) are associated with the development of chronic immune thrombocytopenia in China.
Study represents a comprehensive meta-analysis of the role of IL-17A (show IL17A Proteins) rs2275913 and IL-17F rs763780 polymorphisms in cancer risk and demonstrated that these two polymorphisms significantly increase the risk of development of cancer, particularly gastric cancer.
Polymorphism of IL-17 (show IL17A Proteins) rs3748067 and rs763780 is closely associated with gastric cancer development. Polymorphism of L-17 rs2275913 and rs4711998 may be correlated with the risk for gastric cancer.
ELISA analysis verified high levels of Th17-associated proinflammatory cytokines such as interleukin-17A (show IL17A Proteins)/F, interleukin-6 (show IL6 Proteins) and interleukin-23 and low levels of inflammatory inhibitory factors including interleukin-10 (show IL10 Proteins) and transforming growth factor-beta in primary immune thrombocytopenia patients compared with normal controls.
The GGAGAA combined genotype and the GGA haplotype of IL-17A (show IL17A Proteins) rs2275913, IL-17F rs763780 and rs2397084 can be considered risk factors for the development of systemic lupus erythematosus in Egyptian children.
GA genotype of the rs11465553 IL17F gene polymorphism may be associated with a significantly higher risk of graft function loss and return to dialysis after kidney transplantation.
No associations were found between rs8193036, rs2275913 and rs3748067 in IL-17A (show IL17A Proteins) and rs763780 in IL-17F SNPs and myasthenia gravis in Chinese patients
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
, IL-4-induced secreted protein
, melanoma differentiation-associated gene 7 protein
, th2-specific cytokine FISP
, cytokine-like protein Mob-5
, interleukin 17F
, cytokine ML-1
, mutant IL-17F