IL17F Protein (His tag)

Catalog No. ABIN7320578

Product Details

Target: IL17F (Interleukin 17F (IL17F))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This IL17F protein is labelled with His tag.

Purpose: Recombinant Mouse Interleukin-17F/IL-17F Protein (His Tag)

Sequence: Arg29-Ala161

Characteristics: Recombinant Mouse Interleukin-17F is produced by our Mammalian expression system and the target gene encoding Arg29-Ala161 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL17F (Interleukin 17F (IL17F))

Alternative Name: Interleukin-17F/IL-17F (IL17F Products)

Synonyms: CANDF6 Protein, IL-17F Protein, ML-1 Protein, ML1 Protein, C87042 Protein, IL17F Protein, interleukin 17F Protein, IL17F Protein, Il17f Protein

Background:

Background: Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. Mouse and human IL-17F share 55 % sequence identity.IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).

Synonym: Interleukin-17F, IL-17F, Cytokine ML-1, Interleukin-24, IL-24, IL17F, IL24

Molecular Weight: 15.9 kDa

UniProt: Q7TNI7

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity