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Browse our LILRB2 Proteins (LILRB2)

Full name:
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 Proteins (LILRB2)
On are 16 Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2) Proteins from 9 different suppliers available. Additionally we are shipping LILRB2 Antibodies (48) and LILRB2 Kits (5) and many more products for this protein. A total of 74 LILRB2 products are currently listed.
CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10
list all proteins Gene Name GeneID UniProt
LILRB2 10288 Q8N423

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LILRB2 Proteins (LILRB2) by Origin

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Top referenced LILRB2 Proteins

  1. Human LILRB2 Protein expressed in HEK-293 Cells - ABIN2181472 : Borges, Hsu, Fanger, Kubin, Cosman: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 3 references for ABIN2181472

  2. Human LILRB2 Protein expressed in Human Cells - ABIN2006066 : Willcox, Thomas, Bjorkman: Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. in Nature immunology 2003 (PubMed)

More Proteins for LILRB2 Interaction Partners

Human Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2) interaction partners

  1. LILRB2 expression is significantly upregulated in human masticatory mucosa during wound healing

  2. our results indicate that the ILT4-HLA-G (show HLAG Proteins) interaction might play an important role in Non-small cell lung cancer progression

  3. in systemic lupus erythematosus (SLE) patients, observed an inhibitory effect of ILT4 on the immunogenic capability of Dendritic cells (DC); ILT4 was shown not to have a crucial role in regulating maturation and function of DC from healthy controls but is partially involved in maturation process and immunogenic capability of DC from SLE patients

  4. Data indicate Ig-like transcript 4 (ILT4) as a cellular receptor for complement split products (CSPs) complement component 4d (C4d).

  5. signaling involving ANGPTL2 (show ANGPTL2 Proteins) and LILRB2 is important for lung cancer development

  6. Findings suggest that ILT4 drives NSCLC development in part on activation of ERK (show EPHB2 Proteins) signaling which in turn upregulates VEGF-C (show VEGFC Proteins).

  7. Data show that the leukocyte antigen (show HLADRB4 Proteins) G HLA-G (show HLAG Proteins) alpha1-alpha3 structure, which constitutes the extracellular part of HLA-G2 and HLA-G6, binds the immunologic receptor LILRB2 but not LILRB1 (show LILRB1 Proteins).

  8. Data show that immunoglobulin-like transcript 4 (ILT4) increases the expression of the co-inhibitory molecule B7-H3 (show CD276 Proteins) through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signalling.

  9. involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon (show IFNA Proteins) and vitamin D

  10. A novel motif in the first and fourth Ig domains of LILRB2 was identified that is necessary for the receptor to be bound and activated by Angptl2 (show ANGPTL2 Proteins).

LILRB2 Protein Profile

Protein Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with LILRB2

  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 (LILRB2)
  • CD85D protein
  • ILT-4 protein
  • ILT4 protein
  • LIR-2 protein
  • LIR2 protein
  • MIR-10 protein
  • MIR10 protein

Protein level used designations for LILRB2

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 , leukocyte immunoglobulin-like receptor subfamily B member 2-like , CD85 antigen-like family member D , Ig-like transcript 4 , leukocyte immunoglobulin-like receptor subfamily B member 2 , monocyte/macrophage immunoglobulin-like receptor 10

100433990 Pongo abelii
10288 Homo sapiens
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