LILRB2 Protein (AA 1-461) (His tag)
Quick Overview for LILRB2 Protein (AA 1-461) (His tag) (ABIN7505703)
Target
See all LILRB2 ProteinsProtein Type
Origin
Source
Purity
-
-
Protein Characteristics
- AA 1-461
-
Purification tag / Conjugate
- This LILRB2 protein is labelled with His tag.
-
Sequence
- Met1-Val461
-
Characteristics
- A DNA sequence encoding the Human ILT4(LILRB2) protein (Q8N423) (Met1-Val461) was expressed with a C-His.
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Buffer
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
-
Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
Expiry Date
- 12 months
-
-
- LILRB2 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2))
-
Alternative Name
- ILT4
-
Background
-
Abbreviation: ILT4,LILRB2
Target Synonym: Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2,LIR-2,Leukocyte Immunoglobulin-Like Receptor 2,CD85 Antigen-Like Family Member D,Immunoglobulin-Like Transcript 4,ILT-4,Monocyte/Macrophage Immunoglobulin-Like Receptor 10,MIR-10,CD85d,L
Background: Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
-
Molecular Weight
-
Calculated MW: 50.6 kDa
Observed MW: 75 kDa
-
UniProt
- Q8N423
-
Pathways
- Cellular Response to Molecule of Bacterial Origin
Target
-