Browse our anti-CENPA (CENPA) Antibodies

Full name:
anti-Centromere Protein A Antibodies (CENPA)
On www.antibodies-online.com are 133 Centromere Protein A (CENPA) Antibodies from 20 different suppliers available. Additionally we are shipping CENPA Kits (23) and CENPA Proteins (19) and many more products for this protein. A total of 182 CENPA products are currently listed.
Synonyms:
BcDNA:RE21270, cenH3, CenH3/CID, CenH3[Cid], Cenp-a, CENP-A/Cid, CENP-C, cenpA, CenpA/CID, cenpx, CG13329, Cid, CID/CENP-A, Cid[Mel], Dmel\\CG13329, RGD1563607, sim2
list all antibodies Gene Name GeneID UniProt
CENPA 1058 P49450
CENPA 12615 O35216
CENPA 298850  

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anti-Human CENPA Antibodies:

anti-Mouse (Murine) CENPA Antibodies:

anti-Rat (Rattus) CENPA Antibodies:

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Top referenced anti-CENPA Antibodies

  1. Human Monoclonal CENPA Primary Antibody for ELISA - ABIN394040 : Carroll, Milks, Straight: Dual recognition of CENP-A nucleosomes is required for centromere assembly. in The Journal of cell biology 2010 (PubMed)
    Show all 5 references for 394040

  2. Human Monoclonal CENPA Primary Antibody for ICC, IF - ABIN1027707 : Rieder, Salmon: The vertebrate cell kinetochore and its roles during mitosis. in Trends in cell biology 1998 (PubMed)
    Show all 4 references for 1027707

  3. Human Polyclonal CENPA Primary Antibody for WB - ABIN657764 : Sekulic, Bassett, Rogers, Black: The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. in Nature 2010 (PubMed)
    Show all 2 references for 657764

  4. Human Polyclonal CENPA Primary Antibody for DB, ICC - ABIN2668362 : Logsdon, Barrey, Bassett, DeNizio, Guo, Panchenko, Dawicki-McKenna, Heun, Black: Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. in The Journal of cell biology 2015 (PubMed)

  5. Human Polyclonal CENPA Primary Antibody for IHC, WB - ABIN2782448 : Black, Foltz, Chakravarthy, Luger, Woods, Cleveland: Structural determinants for generating centromeric chromatin. in Nature 2004 (PubMed)

  6. Cow (Bovine) Polyclonal CENPA Primary Antibody for WB - ABIN2782449 : Orthaus, Biskup, Hoffmann, Hoischen, Ohndorf, Benndorf, Diekmann: Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. in Chembiochem : a European journal of chemical biology 2007 (PubMed)

  7. Human Polyclonal CENPA Primary Antibody for IHC, ELISA - ABIN1534330 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)

More Antibodies against CENPA Interaction Partners

Fruit Fly (Drosophila melanogaster) Centromere Protein A (CENPA) interaction partners

  1. centromere assembly factors CAL1 (show CALCA Antibodies) and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility

  2. identify two co-evolving regions, CENP-A L1 and the CAL1 (show CALCA Antibodies) N terminus, as critical for lineage-specific CENP-A incorporation

  3. A novel role has been described for the histone acetyltransferase (show HAT Antibodies) Hat1 (show HAT1 Antibodies) in the CENP-A/CID assembly pathway in Drosophila melanogaster.

  4. CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA

  5. The amount of Cid that is loaded during each cell cycle appears to be determined primarily by the preexisting centromeric Cid, with little flexibility for compensation of accidental losses.

  6. CID nucleosomes are octameric in vivo and that CID dimerization is essential for correct centromere assembly.

  7. The F box protein (show FBXO30 Antibodies) partner of paired (Ppa (show FBXL14 Antibodies)) mediates CenH3(CID) stability in Drosophila. Ppa (show FBXL14 Antibodies) depletion results in increased CenH3(CID) levels. Ppa (show FBXL14 Antibodies) physically interacts with CenH3(CID) through the CATD (show CTSD Antibodies)(CID) that mediates Ppa (show FBXL14 Antibodies)-dependent CenH3(CID) stability.

  8. Drosophila CENP-C is essential for centromere identity.

  9. Cid allows for contacts betwen DNA and histones and specific targeting

  10. Results suggest that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes chromosome missegregation, aneuploidy, and growth defects.

Human Centromere Protein A (CENPA) interaction partners

  1. Evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.

  2. These data implicate the insulin (show INS Antibodies)-FoxM1 (show FOXM1 Antibodies)/PLK1 (show PLK1 Antibodies)/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  3. Findings indicate that expression of the scleroderma autoantigens IFI-16 (show IFI16 Antibodies) and CENPs (show APITD1 Antibodies), which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens.

  4. KAT7 (show MYST2 Antibodies)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1 (show SUV39H1 Antibodies)-mediated heterochromatin invasion into centromeres.

  5. CENP-A mutants that cannot be phosphorylated at Ser68 or ubiquitinated at Lys124 assemble efficiently at centromeres during G1, mediate early events in centromere establishment at an ectopic chromosomal locus, and maintain centromere function indefinitely.

  6. elevated CENP-A expression is coupled to malignant progression of numerous types of cancer. It may be useful as a biomarker of poor patient prognosis and as a predictive biomarker for taxane-based chemotherapy.

  7. CENP-C (show CENPC1 Antibodies) and CENP-I (show CENPI Antibodies) are key factors connecting kinetochore to CENP-A assembly.

  8. The authors found that the nucleosome shape change directed by CENP-A is dominated by lateral passing of two DNA gyres (gyre sliding).

  9. the CRL4 complex containing RBBP7 (show RBBP7 Antibodies) (CRL4(RBBP7 (show RBBP7 Antibodies))) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle.

  10. The DNA ends of the CENP-A nucleosome are more flexible than those of the H3 nucleosome.

Mouse (Murine) Centromere Protein A (CENPA) interaction partners

  1. evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.

  2. These data implicate the insulin (show INS Antibodies)-FoxM1 (show FOXM1 Antibodies)/PLK1 (show PLK1 Antibodies)/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  3. CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.

  4. Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.

  5. Cenpa, Cenpb (show CENPB Antibodies), and Bub3 (show BUB3 Antibodies), but not Cenpc (show CENPC1 Antibodies), interacted with PARP-1 (show PARP1 Antibodies)

  6. The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs (show PRKDC Antibodies) or Ligase IV.

Xenopus laevis Centromere Protein A (CENPA) interaction partners

  1. CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase (show APOBEC3G Antibodies) and UNG2 (show CCNO Antibodies), a uracil DNA glycosylase (show UNG Antibodies).

  2. CENP-A deposition at the centromeres is dependent on HJURP (show HJURP Antibodies).

CENPA Antigen Profile

Antigen Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with CENPA

  • centromere identifier (cid) antibody
  • centromere protein-A (CENP-A) antibody
  • centromere protein A (cenpa) antibody
  • centromeric histone-3 like protein (cenp-A) antibody
  • centromere-specific histone H3 CENP-A (cnp1) antibody
  • cenp-A (HAN_3g422) antibody
  • centromere protein A (Cenp-a) antibody
  • centromere protein A (CENPA) antibody
  • centromere protein A (CMU_016480) antibody
  • centromere protein A (Cenpa) antibody
  • centromere protein A-like (LOC100353660) antibody
  • histone H3-like centromeric protein A (cenpa) antibody
  • BcDNA:RE21270 antibody
  • cenH3 antibody
  • CenH3/CID antibody
  • CenH3[Cid] antibody
  • Cenp-a antibody
  • CENP-A/Cid antibody
  • CENP-C antibody
  • cenpA antibody
  • CenpA/CID antibody
  • cenpx antibody
  • CG13329 antibody
  • Cid antibody
  • CID/CENP-A antibody
  • Cid[Mel] antibody
  • Dmel\\CG13329 antibody
  • RGD1563607 antibody
  • sim2 antibody

Protein level used designations for CENPA

CG13329-PA , centromere identifier protein , centromere protein A , cid-PA , centromere protein-A , centromere protein, Xenopus , histone H3-like centromeric protein A , centromeric histone-3 like protein , cenp-A , centromere autoantigen A , centromere protein A, 17kDa , centromere-specific histone , centrosomin A , CENP-A , ggCENP-A

GENE ID SPECIES
36495 Drosophila melanogaster
407119 Bos taurus
549339 Xenopus (Silurana) tropicalis
857118 Guillardia theta
2539658 Schizosaccharomyces pombe 972h-
5739547 Hemiselmis andersenii
100233153 Nasonia vitripennis
459086 Pan troglodytes
697312 Macaca mulatta
6995376 Cryptosporidium muris RN66
613898 Bos taurus
1058 Homo sapiens
12615 Mus musculus
298850 Rattus norvegicus
475692 Canis lupus familiaris
100724949 Cavia porcellus
100113359 Gallus gallus
101110750 Ovis aries
735079 Xenopus laevis
100689459 Cricetulus griseus
100353660 Oryctolagus cuniculus
100302659 Danio rerio
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